研究実績

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Mochizuki Y, Iida A, Lyons E, Kageyama R, Nakauchi H, Murakami A, Watanabe S.
Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development.
Dev Neurobiol. . :,2013 Oct 1..

Akiyama K, Shimada Y, Higuchi T, Ohtsu M, Nakauchi H, Kobayashi H, Fukuda T, Ida H, Eto Y, Crawford BE, Brown JR, Ohashi T.
Enzyme augmentation therapy enhances the therapeutic efficacy of bone marrow transplantation in mucopolysaccharidosis type II mice.
Mol Genet Metab. . (13):S1096-7192,2013 Sep 21..

NOIMAGE

Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns.
PLoS One. . 8(9):,2013 Sep 23.

Saka K, Kawahara M, Teng J, Otsu M, Nakauchi H, Nagamune T.
Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.
J Biotechnol. . :S0168-1656,2013 Sep 23.

NOIMAGE

Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H.
Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation.
PLoS One. . 8(9):,2013 Sep 16.

Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL.
Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?
Stem Cell Reports. 1(2)::198-208.,2013 Jul 24.

Hirabayashi M, Goto T, Tamura C, Sanbo M, Hara H, Kato-Itoh M, Sato H, Kobayashi T, Nakauchi H, Hochi S.
Derivation of Embryonic Stem Cell Lines From Parthenogenetically Developing Rat Blastocysts.
Stem Cells Dev. . :,2013 Sep 6. .

Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell. . 154(5):1112-26.,2013 Aug 29.

NOIMAGE

Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A.
An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.
PLoS One. . 8(7):e67541:,2013 Jul 25.

Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K.
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.
J Clin Invest. . :,2013 Aug 1.

Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H.
Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.
Biochem Biophys Res Commun. . 435(4):586-91,2013 Jun 14.

NOIMAGE

Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.
Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.
Mol Ther.. 21(7):1424-31,2013 Jul.

Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K.
Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.
Exp Hematol. . 41(8):742-8,2013 Aug.

Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H.
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs.
Proc Natl Acad Sci U S A.. 110(12):4557-62, 2013 Mar 19.

Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M.
Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.
Hepatology. 57(6):2502-13,2013 Jun.

Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Nariai N, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K.
Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.
Proc Natl Acad Sci U S A.. 110(8):3023-8,2013 Feb 19.

Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S.
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
Development. 140(4):740-50, 2013 Jan 14.

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東京大学医科学研究所 幹細胞治療研究センター 幹細胞治療分野 〒108-8639 東京都港区白金台4-6-1 Tel:03-5449-5450 Fax:03-5449-5451 mail:stemcell(at)ims.u-tokyo.ac.jp

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  • 東京大学 医科学研究所
  • 東京大学

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