研究実績

Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Cell Stem Cell. . 12(1):114-26,.2012.11.

NOIMAGE

Matsunari H, Nakano K, Kanai T, Sakai R, Watanabe M, Umeyama K, Kobayashi T, Yamaguchi T, Shiota A, Nagaya M, Nakauchi H, Nagashima H.
326 generation of a double-transgenic pig with pancreas-specific green and liver-specific red fluorescence.
Reprod Fertil Dev. . 25(1):311:,2012 Dec;25.

NOIMAGE

Honda K, Takeuchi Y, Matsuda T, Kanai T, Kuramoto M, Maehara M, Matsunari H, Nakano K, Umeyama K, Watanabe M, Nakauchi H, Nagashima H.
324 production of genetically modified pigs by artificial reproductive technologies using frozen epididymal sperm.
Reprod Fertil Dev. . :309-10.,2012 Dec;25.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Oikawa T, Kamiya A, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM, Nakauchi H.
SALL4, a stem cell biomarker in liver cancers.
Hepatology. hep.26159.:,2012 Nov 23..

Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood. . :,2012 Nov 20..

NOIMAGE

Lin HT, Otsu M, Nakauchi H.
Stem cell therapy: an exercise in patience and prudence.
Philos Trans R Soc Lond B Biol Sci. . 368:,2013 Jan 5.

Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S.
Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation.
Br J Haematol.. :,2012 Nov 1. .

Kamiya A, Nakauchi H.
Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development.
Methods Mol Biol. . 2013;945:273-86.,2013.

Hirabayashi M, Tamura C, Sanbo M, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
A retrospective analysis of germline competence in rat embryonic stem cell lines.
Transgenic Res. . :,2012 Aug 9..

NOIMAGE

Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PLoS One. . 7(7):e41007.:,2012 Jul 18..

NOIMAGE

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PLoS One. . 2012;7(5):,2012 May 11..

Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M.
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood. . 2012 Jun 28;119(26):6234-42, 2012 May 16..

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Blood. . 2012 Jun 28;119(26):6382-93, 2012 May 9..

Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H.
Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells.
Transplant Proc.. 2012 May;44(4):1127-9.,2012.

NOIMAGE

Kobayashi T, Kato-Itoh M, Yamaguchi T, Tamura C, Sanbo M, Hirabayashi M, Nakauchi H.
Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
Stem Cells Dev. . 2012 Jun 11.:,2012.

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Blood. . 2012 Jun 7;119(23):5405-16,2012 Apr 27..

Usui J, Kobayashi T, Yamaguchi T, Knisely AS, Nishinakamura R, Nakauchi H.
Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation.
Am J Pathol. . 2012 Jun;180(6):2417-26, 2012 Apr 14..

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Hirabayashi M, Tamura C, Sanbo M, Goto T, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.
Mol Reprod Dev.. 2012 Jun;79(6):402-12,2012 May 4..

Ghosn EE, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA.
Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.
Proc Natl Acad Sci U S A.. 2012 Apr 3.109(14):5394-8,2012 Mar 19..

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell.. 148(5):1001-14.,2012 .

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
J Exp Med. . :,2012 Feb 20..

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ito H, Kamiya A, Ito K, Yanagida A, Okada K, Nakauchi H.
In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
Liver Int.. :,2012 Jan 4..

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