研究実績

Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
J Biol Chem.. 286(6):4760-71,2010 Dec 7..

NOIMAGE

Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PLoS One. . 5(11):,2010 Nov.

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med. . 207(13):2817-30,2010 Nov 22..

Watanabe M, Umeyama K, Matsunari H, Takayanagi S, Haruyama E, Nakano K, Fujiwara T, Ikezawa Y, Nakauchi H, Nagashima H.
Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases.
Biochem Biophys Res Commun.. 402(1):14-8,2010 Sep 26..

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.

Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A.
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Exp Hematol. . 38(8):696-706,2010 Aug.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J Exp Med.. 207(7):1501-11,2010 Jun 21.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Hepatology. 52:1111-1123,September 2010.

Reprogramming adult hematopoietic cells.

Kaneko S, Otsu M, Nakauchi H.
Reprogramming adult hematopoietic cells.
Curr Opin Hematol. 17(4):271-5,Jul 2010.

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y.
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest.. 90(9):1357-64,2010 Sep.

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clin Cancer Res.. 16(15):3825-31.,2010 Aug 1.

Nakahata S, Yamazaki S, Nakauchi H, Morishita K.
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.
Oncogene. 29(29):4157-69.,2010 Jul 22.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Blood. 115(21):4302-12,2010 May 27.

Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.
Mol Reprod Dev.. 77(6):474,Jun 2010.

Oguro-Cell Stem Cell

Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A.
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Cell Stem Cell. 6(3):279-86,2010.

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