研究実績

Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.
Mol Reprod Dev.. 77(6):474,Jun 2010.

NOIMAGE

Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.
Lnk regulates integrin aIIbb3 outside-in signaling in m ouse platelets leading to stabilization of thrombus development in vivo.
J Clin Invest. 120:179-90,2009.

NOIMAGE

Liao CH, Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
J Clin Invest. 120:242-53,2009.

NOIMAGE

Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H.
Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency.
Mol Reprod Dev. in press:,2009 Nov 6.

NOIMAGE

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.
Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.
Exp Hematol. in press:,2009 Sep 7.

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.

Ishige I, Nagamura-Inoue T, Honda MJ, Harnprasopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A.
Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.
Int J Hematol. 90:261-69,2009.

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T.
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Cancer Cell. 16:161-71,2009.

NOIMAGE

Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature. 460:904-8,2009.

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.

Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H.
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.
Blood. 114:1764-7,2009.

NOIMAGE

Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H.
Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mise.
Gastroenterology.. 137:1114-26,2009.

Insights into signaling and function of hematopoietic stem cells at the single-cell level.

Yamazaki S, Nakauchi H
Insights into signaling and function of hematopoietic stem cells at the single-cell level.
Curr Opin Hematol. 16:255-8,2009.

NOIMAGE

Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H.
Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver.
J Hepatol. 51:127-38,2009.

NOIMAGE

M, atsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.
Stepwise development of hematopoietic stem cells from embryonic stem cells.
PLoS ONE. 4:e4820,2009.

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.

Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T.
T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.
Cytokine. 46:127-36,2009.

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.

Kakinuma S, Nakauchi H, Watanabe M.
Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.
J Gastroenterol. 44:167-72,2009.

NOIMAGE

Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N.
A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.
J Immunol Methods. 343:56-60,2009.

NOIMAGE

Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H.
Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.
Gastroenterology. 136:1000-11,2009.

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.

Yashiro Y, Bannai H, Minowa T, Yabiku T, Miyano S, Osawa M, Iwama A, Nakauchi H.
Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.
Int J Hematol. 89:24-33,2009.

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H.
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem Cells. 27:1120-1129,2009.

TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.

Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H.
TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.
Blood. 113:1250-1256,2009.

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