研究実績

An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.  Cancer Immunol Immunother.

Nabekura T, Nagasawa T, Nakauchi H, Onodera M.
An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.
Cancer Immunol Immunother. 57:611-22,2008.

The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.

Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Romer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Dano K, Hattori K.
The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.
Cell Stem Cell. 1:658-70,2007.

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell Stem Cell. 1:101-12,2007.

NOIMAGE

Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H.
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.
Gastroenterology. 133:937-50,2007.

Cytokine signaling, lipid raft clustering, and HSC hibernation.

Yamazaki S, Iwama A, Morita Y, Eto K, Ema H, Nakauchi H.
Cytokine signaling, lipid raft clustering, and HSC hibernation.
Ann N Y Acad Sci. 1106:54-63,2007.

NOIMAGE

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.
Blood. 110:3637-47,2007.

NOIMAGE

Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H.
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
J Exp Med. 204:715-22,2007.

NOIMAGE

Kato Y, Koseki H, Vidal M, Nakauchi H, Iwama A.
Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.
Int J Hematol. 85:179-81,2007.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita, J., Ema, H., Ooehara, J., Yamazaki, S., Tadokoro, Y., Yamazaki, A., Eto, K., Takaki, S., Takatsu, K., and Nakauchi H.
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.
Proc Natl Acad Sci USA. 104:2349-54,2007.

NOIMAGE

Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.
39. Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells.
Mol Ther. 15:560-5,2007.

NOIMAGE

Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iawama A.
Bmi1 cooperates with Dnmt1-assciated protein 1 in gene silencing.
Biochem Biophys Res Commun. 353:992-8,2007.

NOIMAGE

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Nature Genet. 39:99-105,2007 Epub, 2006.

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