トップページ > 研究実績

研究実績

NOIMAGE

Yamaguchi T, Sato H, Kato-Itoh M, Goto T, Hara H, Sanbo M, Mizuno N, Kobayashi T, Yanagida A, Umino A, Ota Y, Hamanaka S, Masaki H, Rashid ST, Hirabayashi M, Nakauchi H.
Interspecies organogenesis gererates autologous functional islets.
Nature,. :,2017 Jan.

NOIMAGE

Tajima Y, Ito K, Umino A, Wilkinson AC, Nakauchi H, Yamazaki S.
Continuous cell supply from Krt7-expressing hematopoietic stem cells during native hematopoiesis revealed by targeted in vivo gene transfer method.
Sci Rep.. :,2017 Jan.

NOIMAGE

Taya Y, Ota Y, Wilkinson A, Kanezawa A, Watarai H, Kasai M, Nakauchi H, Yamazaki S.
Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation.
Science.. :,2016 Dec.

NOIMAGE

Tarusawa E, Sanbo M, Okayama A, Miyashita T, Kitsukawa T, Hirayama T, Hirabayashi T, Hasegawa S, Kaneko R, Toyoda S, Kobayashi T, Kato-Itoh M, Nakauchi H, Hirabayashi M, Yagi T, Yoshimura Y.
Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins.
BMC Biol.. :,2016 Dec.

NOIMAGE

Wu J, Greely H, Jaenisch R, Nakauchi H, Rossant J, Izpisua Belmonte J.
Stem Cells and Interspecies Chimeras: Past, Present, Future.
Nature.. :,2016 Dec.

NOIMAGE

Ando M, Nakauchi H.
'Off-the-shelf' immunotherapy with iPSC-derived rejuvenated cytotoxic T lymphocytes.
Exp Hematol.. :,2016 Nov.

NOIMAGE

Masaki H, Kato-Itoh M, Takahashi Y, Umino A, Sato H, Ito K, Yanagida A, Nishimura T, Yamaguchi T, Hirabayashi M, Era T, Loh KM, Wu SM, Weissman IL, Nakauchi H.
Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.
Cell Stem Cell.. :,2016 Nov.

NOIMAGE

Yokoi T, Yokoi K, Akiyama K, Higuchi T, Shimada Y, Kobayashi H, Sato T, Ohteki T, Otsu M, Nakauchi H, Ida H, Ohashi T.
Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II.
Mol Genet Metab.. :,2016 Nov.

NOIMAGE

Lin HT, Okumura T, Yatsuda Y, Ito S, Nakauchi H, Otsu M.
Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy.
Hum Gene Ther Methods.. :,2016 Oct.

NOIMAGE

Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
Pre-Transplantation Blockade of TNF-α-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells.
Stem Cells.. :,2016 Oct.

NOIMAGE

Ishida T, Takahashi S, Lai CY, Nojima M, Yamamoto R, Takeuchi E, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation.
J Exp Med. :,2016 Aug.

NOIMAGE

Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-Takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A.
Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes.
Blood.. :,2016 Aug.

NOIMAGE

Goto T, Hara H, Nakauchi H, Hochi S, Hirabayashi M.
Hypomorphic phenotype of Foxn1 gene-modified rats by CRISPR/Cas9 system.
Transgenic Res.. :,2016 Aug.

NOIMAGE

Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K, Heissig B.
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood. :,2016 Aug.

NOIMAGE

Yanagida A, Mizuno N, Yamazaki Y, Kato-Itoh M, Umino A, Sato H, Ito K, Yamaguchi T, Nakauchi H, Kamiya A.
Investigation of bipotent differentiation of hepatoblasts using inducible diphtheria toxin receptor-transgenic mice.
Hepatol Res.. :,2016 Jul.

NOIMAGE

Ueno K, Iwagawa T, Kuribayashi H, Baba Y, Nakauchi H, Murakami A, Nagasaki M, Suzuki Y, Watanabe S.
Transition of differential histone H3 methylation in photoreceptors and other retinal cells during retinal differentiation.
Sci Rep. :,2016 Jul.

NOIMAGE

Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T, Watanabe M.
Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.
Sci Rep.. :,2016 Jul.

NOIMAGE

Durruthy-Durruthy J, Wossidlo M, Pai S, Takahashi Y, Kang G, Omberg L, Chen B, Nakauchi H, Reijo Pera R, Sebastiano V.
Spatiotemporal Reconstruction of the Human Blastocyst by Single-Cell Gene-Expression Analysis Informs Induction of Naive Pluripotency.
Dev Cell.. :,2016 Jul.

NOIMAGE

Noguchi Y, Kawashima Y, Kawara H, Kaneko M, Nakauchi H, Tokuyama Y.
[An Undeniable Case of Optic Neuropathy Due to Cabazitaxel].
Gan To Kagaku Ryoho. . :,2016 Jun.

NOIMAGE

Hayama T, Yamaguchi T, Kato-Itoh M, Ishii Y, Mizuno N, Umino A, Sato H, Sanbo M, Hamanaka S, Masaki H, Hirabayashi M, Nakauchi H.
Practical selection methods for rat and mouse round spermatids without DNA staining by flow cytometric cell sorting.
Mol Reprod Dev.. :,2016 Jun.

NOIMAGE

Hara H, Goto T, Takizawa A, Sanbo M, Jacob HJ, Kobayashi T, Nakauchi H, Hochi S, Hirabayashi M.
Rat Blastocysts from Nuclear Injection and Time-Lagged Enucleation and Their Commitment to Embryonic Stem Cells.
Cell Reprogram.. :, 2016 Apr.

NOIMAGE

Chen JY, Miyanishi M, Wang SK, Yamazaki S, Sinha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL.
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche.
Nature.. :,2016 Feb.

NOIMAGE

Yanagida A, Nakauchi H, Kamiya A.
Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells.
Methods Mol Biol.. :,2016 Feb.

NOIMAGE

Otani S, Kakinuma S, Kamiya A, Goto F, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Kawai-Kitahata F, Nitta S, Nakata T, Okamoto R, Itsui Y, Nakagawa M, Azuma S, Asahina Y, Yamaguchi T, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
Matrix metalloproteinase-14 mediates formation of bile ducts and hepatic maturation of fetal hepatic progenitor cells.
Biochem Biophys Res Commun.. :,2016 Jan.

NOIMAGE

Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.
Fetal Hematopoietic Stem Cell Transplantation Fails to Fully Regenerate the B-Lymphocyte Compartment.
Stem Cell Reports.. :,2016 Jan.

NOIMAGE

Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H.
A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T-Cell Therapy.
Stem Cell Reports. :,2015 Aug.

NOIMAGE

Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama K, Nakauchi H, Kamiya A.
Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner.
Developmental Biology. :,2015 Jul.

NOIMAGE

Yanagida A, Nakauchi H, Kamiya A.
Generation and In Vitro Expansion of Hepatic Progenitor Cells from Human iPS Cells.
Methods Mol Biol. . :,2015 Feb.

NOIMAGE

Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H.
Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model.
Exp Hematol. . 43(2):79-88,2015 Feb.

NOIMAGE

Murayama H, Masaki H, Sato H, Hayama T, Yamaguchi T, Nakauchi H.
Successful reprogramming of epiblast stem cells by blocking nuclear localization of beta-catenin.
Stem Cell Reports. . 4(1):103-13,2015 Jan.

NOIMAGE

Masaki H, Kato-Itoh M, Umino A, Sato H, Hamanaka S, Kobayashi T, Yamaguchi T, Nishimura K, Ohtaka M, Nakanishi M, Nakauchi H.
Interspecific in vitro assay for the chimera-forming ability of human pluripotent stem cells.
Development. . :,2015 Sep.

NOIMAGE

Kobayashi T, Kato-Itoh M, Nakauchi H.
Targeted organ generation using Mixl1-inducible mouse pluripotent stem cells in blastocyst complementation.
Stem Cells Dev. . 24(2):182-9,2015 Jan.

NOIMAGE

Ishigaki T, Zaike Y, Nojima M, Kobayashi S, Ohno N, Uchimaru K, Tojo A, Nakauchi H, Watanabe N.
Quantification of adult T-cell leukemia/lymphoma cells using simple four-color flow cytometry.
Clin Chem Lab Med. . 53(1):85-93,2015 Jan.

NOIMAGE

Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S, Nakauchi H, Ishii Y.
T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of myeloid cells and impairs function of macrophages in the lung.
Blood. . 125(2):370-82,2015 Jan.

NOIMAGE

Yamazaki S, Nakauchi H.
Bone marrow Schwann cells induce hematopoietic stem cell hibernation.
Int J Hematol. . 99(6):695-8,2014 Jun.

NOIMAGE

Yamamoto R, Morita Y, Nakauchi H.
Five-lineage clonal analysis of hematopoietic stem/progenitor cells.
Methods Mol Biol. . 1185:237-45.,2014.

NOIMAGE

Yamaguchi T, Hamanaka S, Nakauchi H.
The generation and maintenance of rat induced pluripotent stem cells.
Methods Mol Biol. . 1210:143-50.,2014.

Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S.
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.
Leukemia. . 28(9):1844-50,2014.

NOIMAGE

Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S.
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.
Leukemia. . 28(9):1844-50,2014 Sep.

NOIMAGE

Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S.
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.
Leukemia. . 28(9):1844-50,2014.

NOIMAGE

Ito K, Yanagida A, Okada K, Yamazaki Y, Nakauchi H, Kamiya A.
Mesenchymal progenitor cells in mouse foetal liver regulate differentiation and proliferation of hepatoblasts.
Liver Int. . 34(9):1378-90,2014 Ocs.

NOIMAGE

Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, Kato-Itoh M, Kakuta S, Iwakura Y, Nakauchi H, Kamiya A.
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
J Biol Chem. . 289(43):29892-911,2014 Oct.

NOIMAGE

Ieyasu A, Tajima Y, Shimba S, Nakauchi H, Yamazaki S.
Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells.
J Negat Results Biomed. . 13:4,2014 Mart.

NOIMAGE

Hayama T, Yamaguchi T, Kato-Itoh M, Hamanaka S, Kawarai M, Sanbo M, Tamura C, Lee YS, Yanagida A, Murayama H, Mizuno N, Umino A, Sato H, Yamazaki S, Masaki H, Kobayashi T, Hirabayashi M, Nakauchi H.
Generation of mouse functional oocytes in rat by xeno-ectopic transplantation of primordial germ cells.
Biol Reprod. . 91(4):89,2014 Oct.

Yamazaki S, Nakauchi H.
Bone marrow Schwann cells induce hematopoietic stem cell hibernation.
Int J Hematol. :,2014 May 10.

Sato A, Nishida C, Sato-Kusubata K, Ishihara M, Tashiro Y, Gritli I, Shimazu H, Munakata S, Yagita H, Okumura K, Tsuda Y, Okada Y, Tojo A, Nakauchi H, Takahashi S, Heissig B, Hattori K.
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.
Leukemia. :,2014 May 5.

Seki M, Masaki H, Arauchi T, Nakauchi H, Sugano S, Suzuki Y.
A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.
PLoS One. 9(4):,2014 Apr 21..

Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H.
Transgenic Pigs with Pancreas-specific Expression of Green Fluorescent Protein.
J Reprod Dev. :,2014 Apr 21..

Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H.
Impaired hematopoietic differentiation of RUNX1-mutated induced pluripotent stem cells derived from FPD/AML patients.
Leukemia. :,2014 Apr 15.

Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M, Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T, Hirabayashi T, Yagi T.
Developmental epigenetic modification regulates stochastic expression of clustered protocadherin genes, generating single neuron diversity.
Neuron. . 82(1):94-108,2014 Apr 2.

Tsukiyama T, Kato-Itoh M, Nakauchi H, Ohinata Y.
A Comprehensive System for Generation and Evaluation of Induced Pluripotent Stem Cells Using piggyBac Transposition.
PLoS One. 9(3):,2014 Mar 25.

Higuchi T, Kawagoe S, Otsu M, Shimada Y, Kobayashi H, Hirayama R, Eto K, Ida H, Ohashi T, Nakauchi H, Eto Y.
The generation of induced pluripotent stem cells (iPSCs) from patients with infantile and late-onset types of Pompe disease and the effects of treatment with acid-α-glucosidase in Pompe's iPSCs.
Mol Genet Metab. . :,2014 Mar 4.

Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M.
A Chemical Probe that Labels Human Pluripotent Stem Cells.
Cell Rep. 6(6):1165-74,2014 Mar 27.

Ieyasu A, Tajima Y, Shimba S, Nakauchi H, Yamazaki S.
Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells.
J Negat Results Biomed. 13(1):,2014 Mar 8.

Yamamoto T, Kai Y, Nakauchi H, Abuku T, Noma Y.
Destruction of polychlorinated naphthalenes by a high-temperature melting treatment (GeoMelt process).
Environ Sci Pollut Res Int. :,2014 Mar 6..

Iida A, Iwagawa T, Kuribayashi H, Satoh S, Mochizuki Y, Baba Y, Nakauchi H, Furukawa T, Koseki H, Murakami A, Watanabe S.
Histone demethylase Jmjd3 is required for the development of subsets of retinal bipolar cells.
Proc Natl Acad Sci U S A.. 111(10):,2014 Mar 11.

Ishihara J, Umemoto T, Yamato M, Shiratsuchi Y, Takaki S, Petrich BG, Nakauchi H, Eto K, Kitamura T, Okano T.
Nov/CCN3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3.
Int J Hematol. . 99(4):393-406,2014 Apr 3.

Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S.
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia.
Leukemia. . :,2014 Feb 18.

Nakamura S, Takayama N, Hirata S, Seo H, Endo H, Ochi K, Fujita K, Koike T, Harimoto K, Dohda T, Watanabe A, Okita K, Takahashi N, Sawaguchi A, Yamanaka S, Nakauchi H, Nishimura S, Eto K.
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
Cell Stem Cell. . 14(4):535-48,2014 Apr 3.

Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A.
The TIF1β-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells.
Stem Cell Reports. . 2(2):145-52,2014 Jan 23.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H.
Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation.
Stem Cells.. :,2014 Feb 8..

NOIMAGE

Ariki R, Morikawa S, Mabuchi Y, Suzuki S, Nakatake M, Yoshioka K, Hidano S, Nakauchi H, Matsuzaki Y, Nakamura T, Goitsuka R.
Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis.
PLoS One. . 9(2):,2014 Feb 3.

Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K.
Immortalization of Erythroblasts by c-MYC and BCL-XL Enables Large-Scale Erythrocyte Production from Human Pluripotent Stem Cells.
Stem Cell Reports.. 1(6):499-508,2013 Dec 5.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Ito K, Yanagida A, Okada K, Yamazaki Y, Nakauchi H, Kamiya A.
Mesenchymal progenitor cells in mouse foetal liver regulate differentiation and proliferation of hepatoblasts.
Liver Int. . liv.12387. :,2013 Nov 15. .

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Mochizuki Y, Iida A, Lyons E, Kageyama R, Nakauchi H, Murakami A, Watanabe S.
Use of cell type-specific transcriptome to identify genes specifically involved in Müller glia differentiation during retinal development.
Dev Neurobiol. . :,2013 Oct 1..

Akiyama K, Shimada Y, Higuchi T, Ohtsu M, Nakauchi H, Kobayashi H, Fukuda T, Ida H, Eto Y, Crawford BE, Brown JR, Ohashi T.
Enzyme augmentation therapy enhances the therapeutic efficacy of bone marrow transplantation in mucopolysaccharidosis type II mice.
Mol Genet Metab. . (13):S1096-7192,2013 Sep 21..

NOIMAGE

Razak SR, Ueno K, Takayama N, Nariai N, Nagasaki M, Saito R, Koso H, Lai CY, Murakami M, Tsuji K, Michiue T, Nakauchi H, Otsu M, Watanabe S.
Profiling of MicroRNA in Human and Mouse ES and iPS Cells Reveals Overlapping but Distinct MicroRNA Expression Patterns.
PLoS One. . 8(9):,2013 Sep 23.

Saka K, Kawahara M, Teng J, Otsu M, Nakauchi H, Nagamune T.
Top-down motif engineering of a cytokine receptor for directing ex vivo expansion of hematopoietic stem cells.
J Biotechnol. . :S0168-1656,2013 Sep 23.

NOIMAGE

Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung UI, Kawaguchi H.
Generation of Col2a1-EGFP iPS Cells for Monitoring Chondrogenic Differentiation.
PLoS One. . 8(9):,2013 Sep 16.

Miyanishi M, Mori Y, Seita J, Chen JY, Karten S, Chan CK, Nakauchi H, Weissman IL.
Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?
Stem Cell Reports. 1(2)::198-208.,2013 Jul 24.

Hirabayashi M, Goto T, Tamura C, Sanbo M, Hara H, Kato-Itoh M, Sato H, Kobayashi T, Nakauchi H, Hochi S.
Derivation of Embryonic Stem Cell Lines From Parthenogenetically Developing Rat Blastocysts.
Stem Cells Dev. . :,2013 Sep 6. .

Yamamoto R, Morita Y, Ooehara J, Hamanaka S, Onodera M, Rudolph KL, Ema H, Nakauchi H.
Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells.
Cell. . 154(5):1112-26.,2013 Aug 29.

NOIMAGE

Yanagida A, Ito K, Chikada H, Nakauchi H, Kamiya A.
An in vitro expansion system for generation of human iPS cell-derived hepatic progenitor-like cells exhibiting a bipotent differentiation potential.
PLoS One. . 8(7):e67541:,2013 Jul 25.

Hirata S, Takayama N, Jono-Ohnishi R, Endo H, Nakamura S, Dohda T, Nishi M, Hamazaki Y, Ishii EI, Kaneko S, Otsu M, Nakauchi H, Kunishima S, Eto K.
Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.
J Clin Invest. . :,2013 Aug 1.

Hamanaka S, Ooehara J, Morita Y, Ema H, Takahashi S, Miyawaki A, Otsu M, Yamaguchi T, Onodera M, Nakauchi H.
Generation of transgenic mouse line expressing Kusabira Orange throughout body, including erythrocytes, by random segregation of provirus method.
Biochem Biophys Res Commun. . 435(4):586-91,2013 Jun 14.

NOIMAGE

Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.
Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.
Mol Ther.. 21(7):1424-31,2013 Jul.

Nakagawa Y, Nakamura S, Nakajima M, Endo H, Dohda T, Takayama N, Nakauchi H, Arai F, Fukuda T, Eto K.
Two differential flows in a bioreactor promoted platelet generation from human pluripotent stem cell-derived megakaryocytes.
Exp Hematol. . 41(8):742-8,2013 Aug.

Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H.
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs.
Proc Natl Acad Sci U S A.. 110(12):4557-62, 2013 Mar 19.

Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M.
Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.
Hepatology. 57(6):2502-13,2013 Jun.

Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Nariai N, Mochizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K.
Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.
Proc Natl Acad Sci U S A.. 110(8):3023-8,2013 Feb 19.

Usui A, Mochizuki Y, Iida A, Miyauchi E, Satoh S, Sock E, Nakauchi H, Aburatani H, Murakami A, Wegner M, Watanabe S.
The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells.
Development. 140(4):740-50, 2013 Jan 14.

Nishimura T, Kaneko S, Kawana-Tachikawa A, Tajima Y, Goto H, Zhu D, Nakayama-Hosoya K, Iriguchi S, Uemura Y, Shimizu T, Takayama N, Yamada D, Nishimura K, Ohtaka M, Watanabe N, Takahashi S, Iwamoto A, Koseki H, Nakanishi M, Eto K, Nakauchi H.
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Cell Stem Cell. . 12(1):114-26,.2012.11.

NOIMAGE

Matsunari H, Nakano K, Kanai T, Sakai R, Watanabe M, Umeyama K, Kobayashi T, Yamaguchi T, Shiota A, Nagaya M, Nakauchi H, Nagashima H.
326 generation of a double-transgenic pig with pancreas-specific green and liver-specific red fluorescence.
Reprod Fertil Dev. . 25(1):311:,2012 Dec;25.

NOIMAGE

Honda K, Takeuchi Y, Matsuda T, Kanai T, Kuramoto M, Maehara M, Matsunari H, Nakano K, Umeyama K, Watanabe M, Nakauchi H, Nagashima H.
324 production of genetically modified pigs by artificial reproductive technologies using frozen epididymal sperm.
Reprod Fertil Dev. . :309-10.,2012 Dec;25.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Oikawa T, Kamiya A, Zeniya M, Chikada H, Hyuck AD, Yamazaki Y, Wauthier E, Tajiri H, Miller LD, Wang XW, Reid LM, Nakauchi H.
SALL4, a stem cell biomarker in liver cancers.
Hepatology. hep.26159.:,2012 Nov 23..

Nakajima-Takagi Y, Osawa M, Oshima M, Takagi H, Miyagi S, Endoh M, Endo TA, Takayama N, Eto K, Toyoda T, Koseki H, Nakauchi H, Iwama A.
Role of SOX17 in hematopoietic development from human embryonic stem cells.
Blood. . :,2012 Nov 20..

NOIMAGE

Lin HT, Otsu M, Nakauchi H.
Stem cell therapy: an exercise in patience and prudence.
Philos Trans R Soc Lond B Biol Sci. . 368:,2013 Jan 5.

Matsuno N, Yamamoto H, Watanabe N, Uchida N, Ota H, Nishida A, Ikebe T, Ishiwata K, Nakano N, Tsuji M, Asano-Mori Y, Izutsu K, Masuoka K, Wake A, Yoneyama A, Nakauchi H, Taniguchi S.
Rapid T-cell chimerism switch and memory T-cell expansion are associated with pre-engraftment immune reaction early after cord blood transplantation.
Br J Haematol.. :,2012 Nov 1. .

Kamiya A, Nakauchi H.
Enrichment and clonal culture of hepatic stem/progenitor cells during mouse liver development.
Methods Mol Biol. . 2013;945:273-86.,2013.

Hirabayashi M, Tamura C, Sanbo M, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
A retrospective analysis of germline competence in rat embryonic stem cell lines.
Transgenic Res. . :,2012 Aug 9..

NOIMAGE

Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Masaki H, Kobayashi T, Yamazaki S, Nakauchi H.
Development of an all-in-one inducible lentiviral vector for gene specific analysis of reprogramming.
PLoS One. . 7(7):e41007.:,2012 Jul 18..

NOIMAGE

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H, Iwama A.
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells.
PLoS One. . 2012;7(5):,2012 May 11..

Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M.
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood. . 2012 Jun 28;119(26):6234-42, 2012 May 16..

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Heissig B, Hattori K.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice.
Blood. . 2012 Jun 28;119(26):6382-93, 2012 May 9..

Sekine K, Takebe T, Suzuki Y, Kamiya A, Nakauchi H, Taniguchi H.
Highly efficient generation of definitive endoderm lineage from human induced pluripotent stem cells.
Transplant Proc.. 2012 May;44(4):1127-9.,2012.

NOIMAGE

Kobayashi T, Kato-Itoh M, Yamaguchi T, Tamura C, Sanbo M, Hirabayashi M, Nakauchi H.
Identification of Rat Rosa26 Locus Enables Generation of Knock-in Rat Lines Ubiquitously Expressing tdTomato.
Stem Cells Dev. . 2012 Jun 11.:,2012.

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Blood. . 2012 Jun 7;119(23):5405-16,2012 Apr 27..

Usui J, Kobayashi T, Yamaguchi T, Knisely AS, Nishinakamura R, Nakauchi H.
Generation of Kidney from Pluripotent Stem Cells via Blastocyst Complementation.
Am J Pathol. . 2012 Jun;180(6):2417-26, 2012 Apr 14..

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Hirabayashi M, Tamura C, Sanbo M, Goto T, Kato-Itoh M, Kobayashi T, Nakauchi H, Hochi S.
Ability of tetraploid rat blastocysts to support fetal development after complementation with embryonic stem cells.
Mol Reprod Dev.. 2012 Jun;79(6):402-12,2012 May 4..

Ghosn EE, Yamamoto R, Hamanaka S, Yang Y, Herzenberg LA, Nakauchi H, Herzenberg LA.
Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cells.
Proc Natl Acad Sci U S A.. 2012 Apr 3.109(14):5394-8,2012 Mar 19..

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL.
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage.
Cell.. 148(5):1001-14.,2012 .

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H, Iwama A.
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
J Exp Med. . :,2012 Feb 20..

NOIMAGE

Takayama N, Eto K, Nakauchi H.
Potential usefulness of human iPS cells on the generation of platelets
Nihon Rinsho.. :,2011 Dec.

NOIMAGE

Kobayashi T, Nakauchi H.
From cell therapy to organ regeneration therapy: generation of functional organs from pluripotent stem cells
Nihon Rinsho.. :,2011 Dec.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ito H, Kamiya A, Ito K, Yanagida A, Okada K, Nakauchi H.
In vitro expansion and functional recovery of mature hepatocytes from mouse adult liver.
Liver Int.. :,2012 Jan 4..

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Umeyama K, Saito H, Kurome M, Matsunari H, Watanabe M, Nakauchi H, Nagashima H.
Characterization of the ICSI-mediated gene transfer method in the production of transgenic pigs.
Mol Reprod Dev.. :218-28,2011 Dec 29..

Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H.
Nonmyelinating schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Cell.. 147(5):1146-58., 2011 Nov 23.

Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, Takaki S.
Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL.
Exp Hematol. . :,2011 Nov 17..

Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T.
Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells.
Blood. . :, 2011 Nov 16. .

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich B, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Blood. . :,2011 Nov 16..

Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B.
Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.
Exp Hematol. . :, 2011 Nov 3..

NOIMAGE

Watanabe M, Kurome M, Matsunari H, Nakano K, Umeyema K, Shiota A, Nakauchi H, Nagashima H.
The creation of transgenic pigs expressing human proteins using BAC-derived, full-length genes and intracytoplasmic sperm injection-mediated gene transfer.
Transgenic Res. . :,2011 Oct 25..

Watabe Y, Baba Y, Nakauchi H, Mizota A, Watanabe S.
The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.
Biochem Biophys Res Commun. . :415(1):42-7., 2011 Nov 11.

NOIMAGE

Ishihara M, Nishida C, Tashiro Y, Gritli I, Rosenkvist J, Koizumi M, Okaji Y, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
Plasmin inhibitor reduces T-cell lymphoid tumor growth by suppressing matrix metalloproteinase-9-dependent CD11b(+)/F4/80(+) myeloid cell recruitment.
Leukemia. . :,2011 Sep 20..

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Saito R, Nakauchi H, Watanabe S.
Serine/threonine kinase, Melk, regulates proliferation and glial differentiation of retinal progenitor cells.
Cancer Sci. . :,2011 Sep 16..

Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.
Frequent pathway mutations of splicing machinery in myelodysplasia.
Nature.. 478: 64–69, 2011 Sep 11.

NOIMAGE

Okada K, Kamiya A, Ito K, Yanagida A, Ito H, Kondou H, Nishina H, Nakauchi H.
Prospective isolation and characterization of bi-potent progenitor cells in early mouse liver development.
Stem Cells Dev. . :,2011 Aug 23.

NOIMAGE

Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H.
Generation of germline-competent rat induced pluripotent stem cells.
PLoS One. :, 2011 Jul 15.

Kawahara M, Chen J, Sogo T, Teng J, Otsu M, Onodera M, Nakauchi H, Ueda H, Nagamune T.
Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera
Cytokine. Volume 55:Pages 402-408,September 2011.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Yokoi T, Kobayashi H, Shimada Y, Higuchi T, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T.
Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease.
J Gene Med. . :,2011 Apr 25.

NOIMAGE

Onozuka I, Kakinuma S, Kamiya A, Miyoshi M, Sakamoto N, Kiyohashi K, Watanabe T, Funaoka Y, Ueyama M, Nakagawa M, Koshikawa N, Seiki M, Nakauchi H, Watanabe M.
Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice.
Biochem Biophys Res Commun. . 406(1):134-40,2011 Mar 4.

Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK.
Hair follicle stem cells provide a functional niche for melanocyte stem cells.
Cell Stem Cell. . 8(2):177-87.,2011 Feb 4.

Morita Y, Iseki A, Okamura S, Suzuki S, Nakauchi H, Ema H.
Functional characterization of hematopoietic stem cells in the spleen.
Exp Hematol. . 39(3):351-359.,2011 Mar.

Nishimura K, Sano M, Ohtaka M, Furuta B, Umemura Y, Nakajima Y, Ikehara Y, Kobayashi T, Segawa H, Takayasu S, Sato H, Motomura K, Uchida E, Kanayasu-Toyoda T, Asashima M, Nakauchi H, Yamaguchi T, Nakanishi M.
Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming.
J Biol Chem.. 286(6):4760-71,2010 Dec 7..

NOIMAGE

Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PLoS One. . 5(11):,2010 Nov.

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med. . 207(13):2817-30,2010 Nov 22..

Watanabe M, Umeyama K, Matsunari H, Takayanagi S, Haruyama E, Nakano K, Fujiwara T, Ikezawa Y, Nakauchi H, Nagashima H.
Knockout of exogenous EGFP gene in porcine somatic cells using zinc-finger nucleases.
Biochem Biophys Res Commun.. 402(1):14-8,2010 Sep 26..

FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.

Sugawara T, Oguro H, Negishi M, Morita Y, Ichikawa H, Iseki T, Yokosuka O, Nakauchi H, Iwama A.
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Exp Hematol. . 38(8):696-706,2010 Aug.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T.
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
J Exp Med.. 207(7):1501-11,2010 Jun 21.

Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.

Chiba T, Seki A, Aoki R, Ichikawa H, Negishi M, Miyagi S, Oguro H, Saraya A, Kamiya A, Nakauchi H, Yokosuka O, Iwama A.
Bmi1 promotes hepatic stem cell expansion and tumorigenicity in both Ink4a/Arf-dependent and -independent manners in mice.
Hepatology. 52:1111-1123,September 2010.

Kobayashi T, Yamaguchi T, Hamanaka S, Kato-Itoh M, Yamazaki Y, Ibata M, Sato H, Lee YS, Usui J, Knisely AS, Hirabayashi M, Nakauchi H.
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.
Cell. 142:787-99,Sep 2010.

Reprogramming adult hematopoietic cells.

Kaneko S, Otsu M, Nakauchi H.
Reprogramming adult hematopoietic cells.
Curr Opin Hematol. 17(4):271-5,Jul 2010.

Mashima R, Honda K, Yang Y, Morita Y, Inoue A, Arimura S, Nishina H, Ema H, Nakauchi H, Seed B, Oda H, Yamanashi Y.
Mice lacking Dok-1, Dok-2, and Dok-3 succumb to aggressive histiocytic sarcoma.
Lab Invest.. 90(9):1357-64,2010 Sep.

Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.

Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clin Cancer Res.. 16(15):3825-31.,2010 Aug 1.

Nakahata S, Yamazaki S, Nakauchi H, Morishita K.
Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma.
Oncogene. 29(29):4157-69.,2010 Jul 22.

Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.

Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Nitta A, Yamada K, Zhu Z, Ogawa H, Yagita H, Okumura K, Nakauchi H, Werb Z, Heissig B, Hattori K.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration.
Blood. 115(21):4302-12,2010 May 27.

Hirabayashi M, Kato M, Sanbo M, Kobayashi T, Hochi S, Nakauchi H.
Rat transgenesis via embryonic stem cells electroporated with the Kusabira-orange gene.
Mol Reprod Dev.. 77(6):474,Jun 2010.

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

Morita Y, Ema H, Nakauchi H.
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
J Exp Med. . 207:1173-1182,April 2010.

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.

Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
Cell Cycle. 9(6).: 1051 - 1056,2010 Mar 23.

Oguro-Cell Stem Cell

Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A.
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Cell Stem Cell. 6(3):279-86,2010.

NOIMAGE

Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K.
Lnk regulates integrin aIIbb3 outside-in signaling in m ouse platelets leading to stabilization of thrombus development in vivo.
J Clin Invest. 120:179-90,2009.

NOIMAGE

Liao CH, Akazawa H, Tamagawa M, Ito K, Yasuda N, Kudo Y, Yamamoto R, Ozasa Y, Fujimoto M, Wang P, Nakauchi H, Nakaya H, Komuro I
Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts
J Clin Invest. 120:242-53,2009.

NOIMAGE

Hirabayashi M, Kato M, Kobayashi T, Sanbo M, Yagi T, Hochi S, Nakauchi H.
Establishment of rat embryonic stem cell lines that can participate in germline chimerae at high efficiency.
Mol Reprod Dev. in press:,2009 Nov 6.

NOIMAGE

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.
Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.
Exp Hematol. in press:,2009 Sep 7.

Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.

Ishige I, Nagamura-Inoue T, Honda MJ, Harnprasopwat R, Kido M, Sugimoto M, Nakauchi H, Tojo A.
Comparison of mesenchymal stem cells derived from arterial, venous, and Wharton's jelly explants of human umbilical cord.
Int J Hematol. 90:261-69,2009.

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

Xiao W, Hong H, Kawakami Y, Kato Y, Wu D, Yasudo H, Kimura A, Kubagawa H, Bertoli LF, Davis RS, Chau LA, Madrenas J, Hsia CC, Xenocostas A, Kipps TJ, Hennighausen L, Iwama A, Nakauchi H, Kawakami T.
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.
Cancer Cell. 16:161-71,2009.

NOIMAGE

Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature. 460:904-8,2009.

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.

Okabe M, Otsu M, Ahn DH, Kobayashi T, Wakiyama Y, Morita Y, Onodera M, Eto K, Ema H, Nakauchi H.
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.
Blood. 114:1764-7,2009.

NOIMAGE

Kamiya A, Kakinuma S, Yamazaki Y, Nakauchi H.
Enrichment and clonal culture of progenitor cells during mouse postnatal liver development in mise.
Gastroenterology.. 137:1114-26,2009.

Insights into signaling and function of hematopoietic stem cells at the single-cell level.

Yamazaki S, Nakauchi H
Insights into signaling and function of hematopoietic stem cells at the single-cell level.
Curr Opin Hematol. 16:255-8,2009.

NOIMAGE

Kakinuma S, Ohta H, Kamiya A, Yamazaki Y, Oikawa T, Okada K, Nakauchi H.
Analyses of cell surface molecules on hepatic stem/progenitor cells in mouse fetal liver.
J Hepatol. 51:127-38,2009.

NOIMAGE

M, atsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.
Stepwise development of hematopoietic stem cells from embryonic stem cells.
PLoS ONE. 4:e4820,2009.

T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.

Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T.
T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.
Cytokine. 46:127-36,2009.

Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.

Kakinuma S, Nakauchi H, Watanabe M.
Hepatic stem/progenitor cells and stem-cell transplantation for the treatment of liver disease.
J Gastroenterol. 44:167-72,2009.

NOIMAGE

Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N.
A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.
J Immunol Methods. 343:56-60,2009.

NOIMAGE

Oikawa T, Kamiya A, Kakinuma S, Zeniya M, Nishinakamura R, Tajiri H, Nakauchi H.
Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells.
Gastroenterology. 136:1000-11,2009.

Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.

Yashiro Y, Bannai H, Minowa T, Yabiku T, Miyano S, Osawa M, Iwama A, Nakauchi H.
Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.
Int J Hematol. 89:24-33,2009.

New ISSCR guidelines underscore major principles for responsible translational stem cell research.

Hyun I, Lindvall O, Ahrlund-Richter L, Cattaneo E, Cavazzana-Calvo M, Cossu G, De Luca M, Fox IJ, Gerstle C, Goldstein RA, Hermerén G, High KA, Kim HO, Lee HP, Levy-Lahad E, Li L, Lo B, Marshak DR, McNab A, Munsie M, Nakauchi H, Rao M, Rooke HM, Valles CS, Srivastava A, Sugarman J, Taylor PL, Veiga A, Wong AL, Zoloth L, Daley GQ.
New ISSCR guidelines underscore major principles for responsible translational stem cell research.
Cell Stem Cell. 3:607-9,2008.

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.

Suzuki A, Sekiya S, Onishi M, Oshima N, Kiyonari H, Nakauchi H, Taniguchi H.
Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver.
Hepatology. 48:1964-78,2008.

NOIMAGE

Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, Yonemitsu Y, Yokosuka O, Taniguchi H, Nakauchi H, Iwama A.
The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma.
Cancer Res. 68:7742-9,2008.

NOIMAGE

Ma F, Ebihara Y, Umeda K, Sakai H, Hanada S, Zhang H, Zaike Y, Tsuchida E, Nakahata T, Nakauchi H, Tsuji K.
Generation of functional erythrocytes from human embryonic stem cell-derived definitive hematopoiesis.
Proc Natl Acad Sci U S A. 105:13087-92,2008.

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H.
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem Cells. 27:1120-1129,2009.

TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.

Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H.
TGF-b induces hibernation of hematopoietic stem cells in the bone marrow niche.
Blood. 113:1250-1256,2009.

Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.

Kamiya A, Kakinuma S, Onodera M, Miyajima A, Nakauchi H.
Prospero-related homeobox 1 and liver receptor homolog 1 coordinately regulate long-term proliferation of murine fetal hepatoblasts.
Hepatology. 48:252-64,2008.

NOIMAGE

Nishikii H, Eto K, Tamura N, Hattori1 K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H.
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.
J Exp Med. 205:1917-27,2008.

Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.

Watanabe N, Takahashi S, Ishige M, Ishii Y, Ooi J, Tomonari A, Tsukada N, Konuma T, Kato S, Sato A, Tojo A, Nakauchi H.
Recipient-derived cells after cord blood transplantation: dynamics elucidated by multicolor FACS, reflecting graft failure and relapse.
Biol Blood Marrow Transplant. 14:693-701,2008.

NOIMAGE

Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H.
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors.
Blood. 111:5298-306,2008.

NOIMAGE

Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S.
Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.
Exp Hematol. 36:897-906,2008.

NOIMAGE

Seita J, Asakawa M, Ooehara J, Takayanagi SI, Morita Y, Watanabe N, Fujita K, Kudo M, Mizuguchi J, Ema H, Nakauchi H, Yoshimoto Y.
Interleukin-27 directly induces differentiation in hematopoietic stem cells.
Blood. 111:1903-12,2008.

An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.  Cancer Immunol Immunother.

Nabekura T, Nagasawa T, Nakauchi H, Onodera M.
An immunotherapy approach with dendritic cells genetically modified to express the tumor-associated antigen, HER2.
Cancer Immunol Immunother. 57:611-22,2008.

The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.

Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Romer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Dano K, Hattori K.
The Plasminogen Fibrinolytic Pathway Is Required for Hematopoietic Regeneration.
Cell Stem Cell. 1:658-70,2007.

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A.
Foxo3a is essential for maintenance of the hematopoietic stem cell pool.
Cell Stem Cell. 1:101-12,2007.

NOIMAGE

Chiba T, Zheng YW, Kita K, Yokosuka O, Saisho H, Onodera M, Miyoshi H, Nakano M, Zen Y, Nakanuma Y, Nakauchi H, Iwama A, Taniguchi H.
Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.
Gastroenterology. 133:937-50,2007.

Cytokine signaling, lipid raft clustering, and HSC hibernation.

Yamazaki S, Iwama A, Morita Y, Eto K, Ema H, Nakauchi H.
Cytokine signaling, lipid raft clustering, and HSC hibernation.
Ann N Y Acad Sci. 1106:54-63,2007.

NOIMAGE

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery.
Blood. 110:3637-47,2007.

NOIMAGE

Tadokoro Y, Ema H, Okano M, Li E, Nakauchi H.
De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.
J Exp Med. 204:715-22,2007.

NOIMAGE

Kato Y, Koseki H, Vidal M, Nakauchi H, Iwama A.
Unique composition of polycomb repressive complex 1 in hematopoietic stem cells.
Int J Hematol. 85:179-81,2007.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita, J., Ema, H., Ooehara, J., Yamazaki, S., Tadokoro, Y., Yamazaki, A., Eto, K., Takaki, S., Takatsu, K., and Nakauchi H.
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.
Proc Natl Acad Sci USA. 104:2349-54,2007.

NOIMAGE

Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.
39. Stable Transgene Expression in Mice Generated from Retrovirally Transduced Embryonic Stem Cells.
Mol Ther. 15:560-5,2007.

NOIMAGE

Negishi M, Saraya A, Miyagi S, Nagao K, Inagaki Y, Nishikawa M, Tajima S, Koseki H, Tsuda H, Takasaki Y, Nakauchi H, Iawama A.
Bmi1 cooperates with Dnmt1-assciated protein 1 in gene silencing.
Biochem Biophys Res Commun. 353:992-8,2007.

NOIMAGE

Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T, Ganser A, Schirmacher P, Nakauchi H, Rudolph KL.
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
Nature Genet. 39:99-105,2007 Epub, 2006.

NOIMAGE

Ema H. Morita Y. Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H.
Adult mouse hematopoietic stem cells: purification and single-cell assays.
Nature Protocols. 1:2979-87,2006.

NOIMAGE

Oguro H, Iwama A, Morita Y, Kamijo T, van Lohuizen M, Nakauchi H.
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice.
J Exp Med. 203:2247-53,2006.

NOIMAGE

Sakaguchi T, Nishimoto M, Miyagi S, Iwama A, Morita Y, Iwamori N, Nakauchi H, Kiyonari H, Muramatsu M, Okuda A.
Putative "stemness" gene jam-B is not required for maintenance of stem cell state in embryonic, neural, or hematopoietic stem cells.
Mol Cell Biol.. 26:6557-70,2006.

NOIMAGE

Yamazaki S, Iwama A, Takayanagi S, Morita Y, Eto K, Ema H, Nakauchi H.
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematpoetic stem cells.
EMBO J. 25:3515-3523,2006.

NOIMAGE

Morita Y, Ema H, Yamazaki S, Nakauchi H.
Non - sicde-population hematopoietic stem cells in mouse bone marrow.
Blood. 108:2850-2856,2006.

Side p opulation purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.

Chiba T, Kita K, Zheng YW, okosuka O, Saisho H, Iwama S, Nakauchi H, Taniguchi H.
Side p opulation purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.
Hepatology. 44:240-51,2006.

NOIMAGE

Furuta C, Ema H, takayanagi S, ogaeri T, Okamura D, Matsui Y, Nakauchi H.
Discordant developmental waves of angioblasts and hemangioblasts in the early gastrulating mouse embryo.
Development. 133:2771-9,2006.

NOIMAGE

Sakaguchi M, Shingo T, Shimazaki T, Okano HJ, Shiwa M, Ishibashi S, Oguro H, Ninomiya M, Kadoya T, Horie H, Shibuya A, Mizusawa H, Poirier F, Nakauchi H, Sawamoto K, Okano H.
A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells.
Proc Natl Acad Sci U S A. 103:7112-7,2006.

NOIMAGE

Takayanagi SI, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H.
Genet ic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell-surface protein with the thrombospondin-1 domain.
Blood. 107:4317-25,2006.

NOIMAGE

Nabekura T, Otsu M, Nagasawa T, Hakauchi H, Onodera M.
Potent Vaccine Therapy with Dendritic Cells Genetically Modified by the Gene-Silencing-Resistant Retroviral Vector GCDNsap.
Molecular Therapy. 13:301-09,2006.

NOIMAGE

Usui J, Osawa M, Yamazaki S, Morita Y, Koyama A, Nakauchi H.
Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting.
Clin Exp Nephrol. 9:292-6,2005.

NOIMAGE

Soriani A, Moran B, de Virgilio M, Kawakami T, Altman A, Lowell C, Eto K, Shattil SJ.
A role for PKCq in outside-in aIIbb3 signaling.
J Thromb Haemost. 4:658-55,2006.

NOIMAGE

Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestweber D, Nakauchi H.
Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development.
J Exp Med. 202:1483-92,2005.

NOIMAGE

Kato Y, Iwama A, Tadokoro Y, Shimoda K, Minoguchi M, Akira S, Tanaka M, Miyajima A, Kitamura T, Nakauchi H.
Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
J Exp Med. 202:169-79,2005.

NOIMAGE

Iseki H, Shimizukawa R, Sugiyama F, Kunita S, Iwama A, Onodera M, Nakauchi H, Yagami K.
Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.
J Virol. 79:8886-93,2005.

NOIMAGE

Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Ichiyanagi T, Kohike H, Komori T, Takahashi I, Takase O, Imai N, Yoshikawa M, Inowa T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.
Musculin/MyoR is expressed in kidney side population cells and can regulate their function.
J Cell Biol. 169:921-8,2005.

NOIMAGE

Ema H, Sudo K, Seita J, Matsubara A, Morita Y, Osawa M, Takatsu K, Takaki S, Nakauchi H.
Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice.
Dev Cell. 8:907-14,2005.

NOIMAGE

Iwama A, Oguro H, Negishi M, Kato Y, and Nakauchi H.
Epigenetic Regulation of Hematopoietic Stem Cell Self-Renewal by Polycomb Group Genes.
Int. Journal of Hematology. 81:294-300,2005.

NOIMAGE

Hishikawa K, Marumo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Kohike H, Komori T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T.
Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16.
Biochem Biophys Res Commun.. 328:288-91,2005.

NOIMAGE

Almeida-Porada G, Crapnell K, Porada C, Benoit B, Nakauchi H, Quesenberry P, Zanjani ED.
In vivo haematopoietic potential of human neural stem cells.
Br J Haematol.. 130:276-83,2005.

NOIMAGE

Kaneko S, Nagasawa T, Nakauchi H, Onodera M.
An in vivo assay for retrovirally transduced human peripheral T lymphocytes using nonobese diabetic/severe combined immunodeficiency mice.
Exp Hematol. 33:35-41,2005.

このページの先頭へ戻る

東京大学医科学研究所 幹細胞治療研究センターについて
東京大学医科学研究所幹細胞治療研究センター
幹細胞治療とは? 詳しくはこちら

東京大学医科学研究所 幹細胞治療研究センター 幹細胞治療分野 〒108-8639 東京都港区白金台4-6-1 Tel:03-5449-5450 Fax:03-5449-5451 mail:stemcell(at)ims.u-tokyo.ac.jp

  • 東京大学医科学研究所幹細胞治療研究センター
  • 東京大学 医科学研究所
  • 東京大学

Copyright 2017 © Center for Stem Cell Biology and Regenerative Medicinell.right reserved.