過去5年間の研究実績

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Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.
Stable transgene expression in mice generated from retrovirally transduced embryonic stem cells.
Mol Ther. 15(3):560-5,2007.

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Cavazzana-Calvo M, Fischer A. Gene therapy: X-SCID transgene leukaemogenicity.
Gene therapy: X-SCID transgene leukaemogenicity.
Nature. 443(7109):E5-6; discussion E-7,2006.

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Suzuki E, Tsutsumi A, Goto D, Matsumoto I, Ito S, Otsu M, Onodera M, Takahashi S, Sato Y, Sumida T.
Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells.
Int J Mol Med. 17(5):801-9., 2006.

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Nabekura T, Otsu M, Nagasawa T, Nakauchi H, Onodera M.
Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap.
Mol Ther. 13(2):301-9, 2006.

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Sakiyama Y, Ariga T, Ohtsu M.
[Gene therapy for adenosine deaminase deficiency].
Nippon Rinsho. 63(3):448-52,2005.

Fujioka H, Ariga T, Yoda M, Ohsaki M, Horiuchi K, Otsu M, Sugihara T, Sakiyama Y.
A case of C3 deficiency with a novel homozygous two-base deletion in the C3 gene.
Am J Med Genet A. 138(4):399-400,2005.

Fujioka H, Ariga T, Horiuchi K, Otsu M, Igawa H, Kawashima K, Yamamoto Y, Sugihara T, Sakiyama Y.
Molecular analysis of non-syndromic preaxial polydactyly: preaxial polydactyly type-IV and preaxial polydactyly type-I.
J Virol Methods. 118(1):61-7. ,J Virol Methods.

Xu L, Tsuji K, Mostowski H, Otsu M, Candotti F, Rosenberg AS.
A convenient method for positive selection of retroviral producing cells generating vectors devoid of selectable markers.
J Virol Methods. 118(1):61-7,2004.

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Otsu M, Hershfield MS, Tuschong LM, Muul LM, Onodera M, Ariga T, Sakiyama Y, Candotti F.
Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy.
Hum Gene Ther. 13(3):425-32,2002.

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Otsu M, Candotti F.
Gene therapy in infants with severe combined immunodeficiency.
BioDrugs. 16(4):229-39,2002.

Yamada M, Matsuura S, Tsukahara M, Ebe K, Ohtsu M, Furuta H, Kobayashi I, Kawamura N, Okano M, Shouji R, Kobayashi K.
Combined immunodeficiency, chromosomal instability, and postnatal growth deficiency in a Japanese girl.
Am J Med Genet. 100(1):9-12,2001.

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Wada T, Schurman SH, Otsu M
Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
Proc Natl Acad Sci U S A. 98(15):8697-702,2001.

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Otsu M, Wada T, Candotti F.
Gene therapy for primary immune deficiencies.
Curr Opin Allergy Clin Immunol. 1(6):497-501,2001.

Otsu M, Sugamura K, Candotti F.
Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice.
Blood. 97(6):1618-24, 2001.

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Aviles Mendoza GJ, Seidel NE, Otsu M, Anderson SM, Simon-Stoos K, Herrera A, Hoogstraten-Miller S, Malech HL, Candotti F, Puck JM, Bodine DM.
Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.
Mol Ther. 3(4):565-73,2001.

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Yamada M, Ariga T, Kawamura N, Yamaguchi K, Ohtsu M, Nelson DL, Kondoh T, Kobayashi I, Okano M, Kobayashi K, Sakiyama Y.
Determination of carrier status for the Wiskott-Aldrich syndrome by flow cytometric analysis of Wiskott-Aldrich syndrome protein expression in peripheral blood mononuclear cells.
J Immunol. 165(2):1119-22,2000.

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Otsu M, Sugamura K, Candotti F.
In vivo competitive studies between normal and common gamma chain-defective bone marrow cells: implications for gene therapy.
Hum Gene Ther. 11(14):2051-6,2000.

Otsu M, Anderson SM, Bodine DM, Puck JM, O'Shea JJ, Candotti F.
Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy.
Mol Ther. 1(2):145-53,2000.

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Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N.
Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release.
J Biol Chem. 275(20):15343-9,2000.

Chinnasamy D, Chinnasamy N, Enriquez MJ, Otsu M, Morgan RA, Candotti F.
Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins.
Blood. 96(4):1309-16,2000.

Yamada M, Ohtsu M, Kobayashi I, Kawamura N, Kobayashi K, Ariga T, Sakiyama Y, Nelson DL, Tsuruta S, Anakura M, Ishikawa N.
Flow cytometric analysis of Wiskott-Aldrich syndrome (WAS) protein in lymphocytes from WAS patients and their familial carriers.
Blood. 93(2):756-7,1999.

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Sakai N, Ohtsu M, Fujita H, Koike T, Kuzumaki N.
Enhancement of G2 checkpoint function by gelsolin transfection in human cancer cells.
Exp Cell Res. 251(1):224-33,1999.

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Okano M, Yamada M, Ohtsu M, Kawamura N, Sakiyama Y, Aoi K, Gandoh S, Fujita M, Kobayashi K.
Successful treatment with methylprednisolone pulse therapy for a life-threatening pulmonary insufficiency in a patient with chronic granulomatous disease following pulmonary invasive aspergillosis and Burkholderia cepacia infection.
Respiration. 66(6):551-4,1999.

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Kawamura N, Ariga T, Ohtsu M, Kobayashi I, Yamada M, Tame A, Furuta H, Okano M, Egashira M, Niikawa N, Kobayashi K, Sakiyama Y.
In vivo kinetics of transduced cells in peripheral T cell-directed gene therapy: role of CD8+ cells in improved immunological function in an adenosine deaminase (ADA)-SCID patient.
J Immunol. 163(4):2256-61,1999.

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Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity GJ, Blaese RM, Sakiyama Y.
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.
Blood. . 91(1):30-6,1998.

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Kawamura N, Ariga T, Ohtsu M, Yamada M, Tame A, Furuta H, Kobayashi I, Okano M, Yanagihara Y, Sakiyama Y.
Elevation of serum IgE level and peripheral eosinophil count during T lymphocyte-directed gene therapy for ADA deficiency: implication of Tc2-like cells after gene transduction procedure.
Immunol Lett. . 64(1):49-53.,1998.

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Kamada S, Kusano H, Fujita H, Ohtsu M, Koya RC, Kuzumaki N, Tsujimoto Y.
A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.
Proc Natl Acad Sci U S A. 95(15):8532-7,1998.

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Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N.
Inhibition of apoptosis by the actin-regulatory protein gelsolin.
Embo J. 16(15):4650-6,1997.

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Osawa M, Hanada K, Hamada H, Nakauchi H.
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
Science.. 273(5272):242-5,1996.

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Ishizaka A, Sakiyama Y, Otsu M, Ozutsumi K, Matsumoto S.
Successful intravenous immunoglobulin therapy for recurrent pneumococcal otitis media in young children.
Eur J Pediatr. 153(3):174-8,1994.

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Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity GJ, Blaese RM, Sakiyama Y.
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.
Blood. . 91(1):30-6, 1998.

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