トップページ > 過去5年間の研究実績

過去5年間の研究実績

Ieyasu, A. Ishida, R. Kimura, T. Morita, M. Wilkinson, A. C. Sudo, K. Nishimura, T. Ohehara, J. Tajima, Y. Lai, C. Y. Otsu, M. Nakamura, Y. Ema, H. Nakauchi, H. Yamazaki, S.
An All-Recombinant Protein-Based Culture System Specifically Identifies Hematopoietic Stem Cell Maintenance Factors
Stem Cell Reports. 8:500-508,2017.

Ishida, T. Suzuki, S. Lai, C. Y. Yamazaki, S. Kakuta, S. Iwakura, Y. Nojima, M. Takeuchi, Y. Higashihara, M. Nakauchi, H. Otsu, M.
Pre-Transplantation Blockade of TNF-alpha-Mediated Oxygen Species Accumulation Protects Hematopoietic Stem Cells
Stem Cells. 35:989-1002,2017.

Ishida, T. Takahashi, S. Lai, C. Y. Nojima, M. Yamamoto, R. Takeuchi, E. Takeuchi, Y. Higashihara, M. Nakauchi, H. Otsu, M.
Multiple allogeneic progenitors in combination function as a unit to support early transient hematopoiesis in transplantation
J Exp Med. 213 (9):1865-1880, 2016.

Glia

Koso, H. Tsuhako, A. Lai, C. Y. Baba, Y. Otsu, M. Ueno, K. Nagasaki, M. Suzuki, Y. Watanabe, S.
Conditional rod photoreceptor ablation reveals Sall1 as a microglial marker and regulator of microglial morphology in the retina
Glia. 64 (11):2005-2024, 2016.

Lin, H. T. Okumura, T. Yatsuda, Y. Ito, S. Nakauchi, H. Otsu, M.
Application of Droplet Digital PCR for Estimating Vector Copy Number States in Stem Cell Gene Therapy
Hum Gene Ther Methods. 27(5):197-208, 2016.

Molecular Genet Metab

Yokoi, T. Yokoi, K. Akiyama, K. Higuchi, T. Shimada, Y. Kobayashi, H. Sato, T. Ohteki, T. Otsu, M. Nakauchi, H. Ida, H. Ohashi, T.
Non-myeloablative preconditioning with ACK2 (anti-c-kit antibody) is efficient in bone marrow transplantation for murine models of mucopolysaccharidosis type II
Mol Genet Metab. 119: 232-238, 2016.

Takashi Ishida, Satoshi Yamazaki, Hiromitsu Nakauchi, Masaaki Higashihara, Makoto Otsu
Reactive oxygen species in hematopoietic stem cells affect culture outcomes under inflammatory conditions
Open Journal of Hematology. 6:, 2015.

Nakazawa, Y. Kawai, T. Uchiyama, T. Goto, F. Watanabe, N. Maekawa, T. Ishiguro, A. Okuyama, T. Otsu, M. Yamada, M. Hershfield, M. S. Ariga, T. Onodera, M.
Effects of enzyme replacement therapy on immune function in ADA deficiency patient
Clinical Immunology. 161(2):391-393,2015.

NOIMAGE

Yamamoto S., Otsu M., Matsuzaka E., Konishi C., Takagi H., Hanada S., Mochizuki S., Nakauchi H., Imai K., Tsuji K., Ebihara Y.
Screening of drugs to treat 8p11 myeloproliferative syndrome using patient-derived induced pluripotent stem cells with fusion gene CEP110-FGFR1.
PLoS One. 10:e0120841, 2015.

NOIMAGE

Toriumi T., Takayama N., Murakami M., Sato M., Yuguchi M., Yamazaki Y., Eto K., Otsu M., Nakauchi H., Shirakawa T., Isokawa K., Honda M.J.
Characterization of mesenchymal progenitor cells in the crown and root pulp of primary teeth.
Biomed Res.. 36:31-45,2015.

Yasuo Takeuchi, Emiko Takeuchi, Takashi Ishida, Masafumi Onodera, Hiromitsu Nakauchi, Makoto Otsu
Curative haploidentical BMT in a murine model of X-linked chronic granulomatous disease
International Journal of Hematology. 102:111-20,2015.

Otsu M., Yamada M., Nakajima S., Kida M., Maeyama Y., Hatano N., Toita N., Takezaki S., Okura Y., Kobayashi R., Matsumoto Y., Tatsuzawa O., Tsuchida F., Kato S., Kitagawa M., Mineno J., Hershfield M. S., Bali P., Candotti F., Onodera M., Kawamura N., Sakiyama Y., Ariga T.
Outcomes in two Japanese adenosine deaminase-deficiency patients treated by stem cell gene therapy with no cytoreductive conditioning
J Clin Immunol. 35:384-398,2015.

NOIMAGE

Yokoi K., Akiyama K., Kaneshiro E., Higuchi T., Shimada Y., Kobayashi H., Akiyama M., Otsu M., Nakauchi H., Ohashi T., Ida H.
Effect of donor chimerism to reduce the level of glycosaminoglycans following bone marrow transplantation in a murine model of mucopolysaccharidosis type II
Journal of inherited metabolic disease. 38:333-340,2015.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.
Blood. 123(25):3932-3942,2014.

NOIMAGE

Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S.
Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia
Leukemia. 73:,2014.

Lai, C. Y. Yamazaki, S. Okabe, M. Suzuki, S. Maeyama, Y. Iimura, Y. Onodera, M. Kakuta, S. Iwakura, Y. Nojima, M. Otsu, M. Nakauchi, H.
Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation
Stem Cells. 32(7):1929-42,2014 Jul.

Nishimura S, Manabe I, Nagasaki M, Kakuta S, Iwakura Y, Takayama N, Ooehara J, Otsu M, Kamiya A, Petrich BG, Urano T, Kadono T, Sato S, Aiba A, Yamashita H, Sugiura S, Kadowaki T, Nakauchi H, Eto K, Nagai R.
In vivo imaging visualizes discoid platelet aggregations without endothelium disruption and implicates contribution of inflammatory cytokine and integrin signaling.
Blood. 119(8):e45-56,2012.

Kumano K, Arai S, Hosoi M, Taoka K, Takayama N, Otsu M, Nagae G, Ueda K, Nakazaki K, Kamikubo Y, Eto K, Aburatani H, Nakauchi H, Kurokawa M.
Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.
Blood. . 119(26):6234-42,2012.

NOIMAGE

Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S.
Frequent pathway mutations of splicing machinery in myelodysplasia.
Nature. . 478(7367):64-9,2011.

Yokoi T, Kobayashi H, Shimada Y, Eto Y, Ishige N, Kitagawa T, Otsu M, Nakauchi H, Ida H, Ohashi T.
Minimum requirement of donor cells to reduce the glycolipid storage following bone marrow transplantation in a murine model of Fabry disease.
J Gene Med.. 13(5):262-8,2011.

NOIMAGE

Maeyama Y, Otsu M, Kubo S, Yamano T, Iimura Y, Onodera M, Kondo S, Sakiyama Y, Ariga T.
Intracellular estrogen receptor-binding fragment-associated antigen 9 exerts in vivo tumor-promoting effects via its coiled-coil region.
Int J Oncol. . 39(1):41-9,2011.

Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H.
Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.
Blood. . 117(20):5479-84,2011.

Kawahara M, Chen J, Sogo T, Teng J, Otsu M, Onodera M, Nakauchi H, Ueda H, Nagamune T.
Growth promotion of genetically modified hematopoietic progenitors using an antibody/c-Mpl chimera.
Cytokine. 55(3):402-8,2011.

Sogo T, Kawahara M, Ueda H, Otsu M, Onodera M, Nakauchi H, Nagamune T.
T cell growth control using hapten-specific antibody/interleukin-2 receptor chimera.
Cytokine. 46(1):127-36, 2009.

Takayama N, Nishimura S, Nakamura S, Shimizu T, Ohnishi R, Endo H, Yamaguchi T, Otsu M, Nishimura K, Nakanishi M, Sawaguchi A, Nagai R, Takahashi K, Yamanaka S, Nakauchi H, Eto K.
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells.
J Exp Med. 207(13):2817-30,2010.

NOIMAGE

Otsu M.
[Gene and cell therapy for primary immunodeficiency diseases].
Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology. 33(6):312-6,2010.

Ogawa S, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP, Sanada M.
Deregulated intracellular signaling by mutated c-CBL in myeloid neoplasms.
Clin Cancer Res. 16(15):3825-31,2010.

NOIMAGE

Ogawa S, Sanada M, Shih LY, Suzuki T, Otsu M, Nakauchi H, Koeffler HP.
Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms.
Cell Cycle. 9(6) :1051-6 ,2010.

NOIMAGE

Kaneko S, Otsu M, Nakauchi H.
Reprogramming adult hematopoietic cells.
Curr Opin Hematol. 17(4):271-5,2010.

NOIMAGE

Hayashi Y, Chan T, Warashina M, Fukuda M, Ariizumi T, Okabayashi K, Takayama N, Otsu M, Eto K, Furue MK, Michiue T, Ohnuma K, Nakauchi H, Asashima M.
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.
PLoS One. 5(11):e14099,2010.

NOIMAGE

Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Nature. 460(7257):904-8,2009.

Okabe M, Otsu M, Ahn DH, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H, Nakauchi H.
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.
Blood. 114(9):1764-7, 2009.

Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H.
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells
Stem Cells. 2009;27(5):1120-9:1120-9,2009.

NOIMAGE

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Ueki K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R.
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity.
Nat Med. 15(8):914-20, 2009.

NOIMAGE

Horiuchi Y, Onodera M, Miyagawa Y, Sato B, Onda K, Katagiri YU, Okita H, Okada M, Otsu M, Kume A, Okuyama T, Fujimoto J, Kuratsuji T, Kiyokawa N.
Kinetics and effect of integrin expression on human CD34(+) cells during murine leukemia virus-derived retroviral transduction with recombinant fibronectin for stem cell gene therapy.
Hum Gene Ther. 20(7):777-83, 2009.

Fujisawa Y, Nabekura T, Nakao T, Nakamura Y, Takahashi T, Kawachi Y, Otsuka F, Onodera M.
The induction of tumor-specific CD4+ T cells via major histocompatibility complex class II is required to gain optimal anti-tumor immunity against B16 melanoma cell line in tumor immunotherapy using dendritic cells.
Exp Dermatol. 18(4):396-403,2009.

Sanuki S, Hamanaka S, Kaneko S, Otsu M, Karasawa S, Miyawaki A, Nakauchi H, Nagasawa T, Onodera M.
A new red fluorescent protein that allows efficient marking of murine hematopoietic stem cells.
The journal of gene medicine. 10(9):965-71, 2008.

Fujioka H, Ariga T, Horiuchi K, Ishikiriyama S, Oyama K, Otsu M, Kawashima K, Yamamoto Y, Sugihara T, Sakiyama Y.
Detection of a novel silent deletion, a missense mutation and a nonsense mutation in TCOF1.
Pediatr Int. 50(6):806-9, 2008.

NOIMAGE

Hamanaka S, Nabekura T, Otsu M, Yoshida H, Nagata M, Usui J, Takahashi S, Nagasawa T, Nakauchi H, Onodera M.
Stable transgene expression in mice generated from retrovirally transduced embryonic stem cells.
Mol Ther. 15(3):560-5,2007.

NOIMAGE

Cavazzana-Calvo M, Fischer A. Gene therapy: X-SCID transgene leukaemogenicity.
Gene therapy: X-SCID transgene leukaemogenicity.
Nature. 443(7109):E5-6; discussion E-7,2006.

NOIMAGE

Suzuki E, Tsutsumi A, Goto D, Matsumoto I, Ito S, Otsu M, Onodera M, Takahashi S, Sato Y, Sumida T.
Gene transduction of tristetraprolin or its active domain reduces TNF-alpha production by Jurkat T cells.
Int J Mol Med. 17(5):801-9., 2006.

NOIMAGE

Nabekura T, Otsu M, Nagasawa T, Nakauchi H, Onodera M.
Potent vaccine therapy with dendritic cells genetically modified by the gene-silencing-resistant retroviral vector GCDNsap.
Mol Ther. 13(2):301-9, 2006.

NOIMAGE

Sakiyama Y, Ariga T, Ohtsu M.
[Gene therapy for adenosine deaminase deficiency].
Nippon Rinsho. 63(3):448-52,2005.

Fujioka H, Ariga T, Yoda M, Ohsaki M, Horiuchi K, Otsu M, Sugihara T, Sakiyama Y.
A case of C3 deficiency with a novel homozygous two-base deletion in the C3 gene.
Am J Med Genet A. 138(4):399-400,2005.

Fujioka H, Ariga T, Horiuchi K, Otsu M, Igawa H, Kawashima K, Yamamoto Y, Sugihara T, Sakiyama Y.
Molecular analysis of non-syndromic preaxial polydactyly: preaxial polydactyly type-IV and preaxial polydactyly type-I.
J Virol Methods. 118(1):61-7. ,J Virol Methods.

Xu L, Tsuji K, Mostowski H, Otsu M, Candotti F, Rosenberg AS.
A convenient method for positive selection of retroviral producing cells generating vectors devoid of selectable markers.
J Virol Methods. 118(1):61-7,2004.

NOIMAGE

Otsu M, Hershfield MS, Tuschong LM, Muul LM, Onodera M, Ariga T, Sakiyama Y, Candotti F.
Flow cytometry analysis of adenosine deaminase (ADA) expression: a simple and reliable tool for the assessment of ADA-deficient patients before and after gene therapy.
Hum Gene Ther. 13(3):425-32,2002.

NOIMAGE

Otsu M, Candotti F.
Gene therapy in infants with severe combined immunodeficiency.
BioDrugs. 16(4):229-39,2002.

Yamada M, Matsuura S, Tsukahara M, Ebe K, Ohtsu M, Furuta H, Kobayashi I, Kawamura N, Okano M, Shouji R, Kobayashi K.
Combined immunodeficiency, chromosomal instability, and postnatal growth deficiency in a Japanese girl.
Am J Med Genet. 100(1):9-12,2001.

NOIMAGE

Wada T, Schurman SH, Otsu M
Somatic mosaicism in Wiskott--Aldrich syndrome suggests in vivo reversion by a DNA slippage mechanism.
Proc Natl Acad Sci U S A. 98(15):8697-702,2001.

NOIMAGE

Otsu M, Wada T, Candotti F.
Gene therapy for primary immune deficiencies.
Curr Opin Allergy Clin Immunol. 1(6):497-501,2001.

Otsu M, Sugamura K, Candotti F.
Lack of dominant-negative effects of a truncated gamma(c) on retroviral-mediated gene correction of immunodeficient mice.
Blood. 97(6):1618-24, 2001.

NOIMAGE

Aviles Mendoza GJ, Seidel NE, Otsu M, Anderson SM, Simon-Stoos K, Herrera A, Hoogstraten-Miller S, Malech HL, Candotti F, Puck JM, Bodine DM.
Comparison of five retrovirus vectors containing the human IL-2 receptor gamma chain gene for their ability to restore T and B lymphocytes in the X-linked severe combined immunodeficiency mouse model.
Mol Ther. 3(4):565-73,2001.

NOIMAGE

Yamada M, Ariga T, Kawamura N, Yamaguchi K, Ohtsu M, Nelson DL, Kondoh T, Kobayashi I, Okano M, Kobayashi K, Sakiyama Y.
Determination of carrier status for the Wiskott-Aldrich syndrome by flow cytometric analysis of Wiskott-Aldrich syndrome protein expression in peripheral blood mononuclear cells.
J Immunol. 165(2):1119-22,2000.

NOIMAGE

Otsu M, Sugamura K, Candotti F.
In vivo competitive studies between normal and common gamma chain-defective bone marrow cells: implications for gene therapy.
Hum Gene Ther. 11(14):2051-6,2000.

Otsu M, Anderson SM, Bodine DM, Puck JM, O'Shea JJ, Candotti F.
Lymphoid development and function in X-linked severe combined immunodeficiency mice after stem cell gene therapy.
Mol Ther. 1(2):145-53,2000.

NOIMAGE

Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N.
Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release.
J Biol Chem. 275(20):15343-9,2000.

Chinnasamy D, Chinnasamy N, Enriquez MJ, Otsu M, Morgan RA, Candotti F.
Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins.
Blood. 96(4):1309-16,2000.

Yamada M, Ohtsu M, Kobayashi I, Kawamura N, Kobayashi K, Ariga T, Sakiyama Y, Nelson DL, Tsuruta S, Anakura M, Ishikawa N.
Flow cytometric analysis of Wiskott-Aldrich syndrome (WAS) protein in lymphocytes from WAS patients and their familial carriers.
Blood. 93(2):756-7,1999.

NOIMAGE

Sakai N, Ohtsu M, Fujita H, Koike T, Kuzumaki N.
Enhancement of G2 checkpoint function by gelsolin transfection in human cancer cells.
Exp Cell Res. 251(1):224-33,1999.

NOIMAGE

Okano M, Yamada M, Ohtsu M, Kawamura N, Sakiyama Y, Aoi K, Gandoh S, Fujita M, Kobayashi K.
Successful treatment with methylprednisolone pulse therapy for a life-threatening pulmonary insufficiency in a patient with chronic granulomatous disease following pulmonary invasive aspergillosis and Burkholderia cepacia infection.
Respiration. 66(6):551-4,1999.

NOIMAGE

Kawamura N, Ariga T, Ohtsu M, Kobayashi I, Yamada M, Tame A, Furuta H, Okano M, Egashira M, Niikawa N, Kobayashi K, Sakiyama Y.
In vivo kinetics of transduced cells in peripheral T cell-directed gene therapy: role of CD8+ cells in improved immunological function in an adenosine deaminase (ADA)-SCID patient.
J Immunol. 163(4):2256-61,1999.

NOIMAGE

Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity GJ, Blaese RM, Sakiyama Y.
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.
Blood. . 91(1):30-6,1998.

NOIMAGE

Kawamura N, Ariga T, Ohtsu M, Yamada M, Tame A, Furuta H, Kobayashi I, Okano M, Yanagihara Y, Sakiyama Y.
Elevation of serum IgE level and peripheral eosinophil count during T lymphocyte-directed gene therapy for ADA deficiency: implication of Tc2-like cells after gene transduction procedure.
Immunol Lett. . 64(1):49-53.,1998.

NOIMAGE

Kamada S, Kusano H, Fujita H, Ohtsu M, Koya RC, Kuzumaki N, Tsujimoto Y.
A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin.
Proc Natl Acad Sci U S A. 95(15):8532-7,1998.

NOIMAGE

Ohtsu M, Sakai N, Fujita H, Kashiwagi M, Gasa S, Shimizu S, Eguchi Y, Tsujimoto Y, Sakiyama Y, Kobayashi K, Kuzumaki N.
Inhibition of apoptosis by the actin-regulatory protein gelsolin.
Embo J. 16(15):4650-6,1997.

NOIMAGE

Osawa M, Hanada K, Hamada H, Nakauchi H.
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
Science.. 273(5272):242-5,1996.

NOIMAGE

Ishizaka A, Sakiyama Y, Otsu M, Ozutsumi K, Matsumoto S.
Successful intravenous immunoglobulin therapy for recurrent pneumococcal otitis media in young children.
Eur J Pediatr. 153(3):174-8,1994.

Lnk regulates integrin IIb3 outside-in signaling in mouse platelets leading to stabilization of thrombus development in vivo

Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K
Lnk regulates integrin [alpha]IIb[beta]3 outside-in signaling in mouse platelets leading to stabilization of thrombus development in vivo
J Clin Invest. 120:179-90,2010.

Evidence that integrin IIb3-dependent interaction of mast cells with fibrinogen exacerebrates chronic inflammation

Oki T, Eto K, Izawa K, Yamanishi Y, Inagaki N, Frampton J, Kitamura T, Kitaura J
Evidence that integrin [alpha]IIb[beta]3-dependent interaction of mast cells with fibrinogen exacerebrates chronic inflammation
J Biol Chem. 284(45):31463-72,2009.

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, Ohsugi M, Otsu M, Hara K, Sugiura S, Yoshimura K, Kadowaki T, Nagai R
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
Nat Med. 15(8):914-20,2009.

Definitive proof for direct reprogramming of hematopoietic cells to pluripotency

Okabe M, Otsu M, Ahn DH, Kobayashi T, Morita Y, Wakiyama Y, Onodera M, Eto K, Ema H, Nakauchi H
Definitive proof for direct reprogramming of hematopoietic cells to pluripotency
Blood. 114(9):1764-67,2009.

The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.

Ogaeri T, Eto K, Otsu M, Ema H, Nakauchi H
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
Stem Cells. 27(5):1120-29,2009.

TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.
Blood. 113(6):1250-6,2009.

NOIMAGE

Matsumoto K, Isagawa T, Nishimura T, Ogaeri T, Eto K, Miyazaki S, Miyazaki J, Aburatani H, Nakauchi H, Ema H.
Stepwise development of hematopoietic stem cells from embryonic stem cells
PLosONE. 4(3):e4820,2009.

Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells

Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells
J Exp Med . 205:1917-27,2008.

Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors

Takayama N, Nishikii H, Usui J, Tsukui H, Sawaguchi A, Hiroyama T, Eto K, Nakauchi H
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
Blood. 111:5298-5306,2008.

NOIMAGE

Takizawa H, Eto K, Yoshikawa A, Nakauchi H, Takatsu K, Takaki S.
Growth and maturation of megakaryocytes is regulated by Lnk/SH2B3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals
Exp Hematol. 36:897-906,2008.

The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery

Eto K, Nishikii H, Ogaeri T, Suetsugu S, Kamiya A, Kobayashi T, Yamazaki D, Oda A, Takenawa T, Nakauchi H.
The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
Blood. 110:3637-47,2007.

Cytokine signaling, lipid raft clustering, and HSC hibernation

Yamazaki S, Iwama A, Morita Y, Eto K, Ema H, Nakauchi H
Cytokine signaling, lipid raft clustering, and HSC hibernation
Ann N Y Acad Sci. 1106:54-63,2007.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Proc Natl Acad Sci U S A. 104(7):2349-54,2007.

NOIMAGE

Onodera M, Ariga T, Kawamura N, Kobayashi I, Ohtsu M, Yamada M, Tame A, Furuta H, Okano M, Matsumoto S, Kotani H, McGarrity GJ, Blaese RM, Sakiyama Y.
Successful peripheral T-lymphocyte-directed gene transfer for a patient with severe combined immune deficiency caused by adenosine deaminase deficiency.
Blood. . 91(1):30-6, 1998.

このページの先頭へ戻る

東京大学医科学研究所 幹細胞治療研究センターについて
東京大学医科学研究所幹細胞治療研究センター
幹細胞治療とは? 詳しくはこちら

東京大学医科学研究所 幹細胞治療研究センター 幹細胞プロセシング分野/ステムセルバンク 〒108-8639 東京都港区白金台4-6-1 Tel:03-5449-5397Fax:03-5449-5428 imsutscb(at)ims.u-tokyo.ac.jp

  • 東京大学医科学研究所幹細胞治療研究センター
  • 東京大学医科学研究所附属病院
  • 東京大学 医科学研究所
  • 東京大学

Copyright 2017 © Center for Stem Cell Biology and Regenerative Medicinell.right reserved.