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Shimazu H, Munakata S, Tashiro Y, Salama Y, Eiamboonsert S, Ota Y, Onoda H, Tsuda Y, Okada Y, Nakauchi H, Heissig B, Hattori K.
Pharmacological targeting of plasmin prevents lethality and tissue damage in a murine model of macrophage activation syndrome.
Blood. :,2017 Mar 21 [Epub ahead of print].

Honjo K, Shinya Munakata S, Tashiro Y, Salama Y, Shimazu H, Eiamboonsert S, Dhahri D, Ichimura A, Dan T, Miyata T, Takeda K, Sakamoto K, Hattori K, Heissig B.
Plasminogen activator inhibitor-1 regulates macrophage-dependent postoperative adhesion by enhancing EGF-HER1 signaling in mice.
FASEB. :,2017 Mar 7 [Epub ahead of print].

Dhahri D, Sato-Kusubata K, Ohki-Koizumi M, Nishida C, Tashiro Y, Munakata S, Shimazu H, Salama Y, Eiamboonsert S, Nakauchi H, Hattori K and Heissig B.
Fibrinolytic crosstalk with endothelial cells expands murine mesenchymal stromal cells.
Blood. :,2016 Aug 25.

Heissig B, Eiamboonsert S, Salama Y, Shimazu H, Dhahri D, Munakata S, Tashiro Y, Hattori K.
Cancer therapy targeting the fibrinolytic system.
Adv Drug Deliv Rev. 2015 Nov 14. pii: S0169-409X(15)00274-4. doi: 10.1016/j.addr.2015.11.010. [Epub ahead of print] Review.. :,2015.

Heissig B, Dhahri D, Eiamboonsert S, Salama Y, Shimazu H, Munakata S, Hattori K.
Role of mesenchymal stem cell-derived fibrinolytic factor in tissue regeneration and cancer progression.
Cell Mol Life Sci. :,2015 Sep 9. [Epub ahead of print].

Inhibition of Plasmin Protects Against Colitis in Mice by Suppressing Matrix Metalloproteinase 9-Mediated Cytokine Release From Myeloid Cells.

Munakata S, Tashiro Y, Nishida C, Sato A, Komiyama H, Shimazu H, Dhahri D, Salama Y, Eiamboonsert S, Takeda K, Yagita H, Tsuda Y, Okada Y, Nakauchi H, Sakamoto K, Heissig B, Hattori K.
Inhibition of Plasmin Protects Against Colitis in Mice by Suppressing Matrix Metalloproteinase 9-Mediated Cytokine Release From Myeloid Cells.
Gastroenterology . 148:565-578.e4,2015.

A Sato, C Nishida, K Sato-Kusubata, M Ishihara, Y Tashiro, I Gritli, H Shimazu, S Munakata, H Yagita, K Okumura, Y Tsuda, Y Okada, A Tojo, H Nakauchi, S Takahashi, B Heissig and K Hattori
Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.
Leukemia. 29:145-56,2015.

Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells.
Blood. 123:3932-42,2014.

Caiado F, Carvalho T, Rosa I, Remédio L, Costa A, Matos J, Heissig B, Yagita H, Hattori K, da Silva JP, Fidalgo P, Pereira AD, Dias S.
Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer.
Cancer Res.. 73(14):4233-4246,2013.

Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice

Tashiro Y, Nishida C, Sato-Kusubata K, Ohki-Koizumi M, Ishihara M, Sato A, Gritli I, Komiyama H, Sato Y, Dan T, Miyata T, Okumura K, Tomiki Y, Sakamoto K, Nakauchi H, Hattori K, Heissig B.
Inhibition of PAI-1 induces neutrophil-driven neoangiogenesis and promotes tissue regeneration via production of angiocrine factors in mice
Blood. 119(26):6382-93,2012.

MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells

Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells
Blood. 119(23):5405-16,2012.

Heissig B, Ohki-Koizumi M, Tashiro Y, Gritli I, Sato-Kusubata K, Hattori K.
New functions of the fibrinolytic system in bone marrow cell-derived angiogenesis.
Int J Hematol. 95(2):131-7,2012.

Okaji Y, Tashiro Y, Gritli I, Nishida C, Sato A, Ueno Y, Del Canto Gonzalez S, Ohki-Koizumi M, Akiyama H, Nakauchi H, Hattori K, Heissig B.
Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.
Exp Hematol. 40(2):143-54,2012.

Ishihara M, Nishida C, Tashiro Y, Ismael Gritli I, Rosenkvist J, Koizumi M, Okaji Y, Yamamoto R, Yagita H, Okumura K, Nishikori M, Wanaka K, Yuko Tsuda Y, Okada Y, Nakauchi H, , Hattori K, Heissig B.
Plasmin inhibitor reduces lymphoid tumor growth by suppressing matrix metallproteinase-9 dependent CD11b+/F4/80+ myeloid cell recruitment.
Leukemia.. 26(2):332-9,2011.

Piao JH, Hasegawa M, Heissig B, Hattori K, Takeda K, Iwakura Y, Okumura K, Inohara N, Nakano H.
Tumor necrosis factor receptor-associated factor (Traf)2 controls homeostasis of the colon to prevent spontaneous development of murine inflammatory bowel disease.
J Biol Chem. 286(20):17879-88,2011.

Heissig B, Nishida C, Tashiro Y, Sato Y, Ishihara M, Ohki M, Gritli I, Rosenkvist J, Hattori K.
Role of neutrophil-derived matrix metalloproteinase-9 in tissue regeneration.
Histol Histopathol. 25(6):765-70,2010.

Ohki M, Ohki Y, Ishihara M, Nishida C, Tashiro Y, Akiyama H, Komiyama H, Lund LR, Atsumi Nitta A, Yamada, K, Zhu Z, Ogawa, H, Yagita H, Okumura K, Nakauchi H, Werb Z, Hattori K, Heissig B.
Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneneration.
Blood. 115(21):4302-12115,2010.

Aoki N, Yokoyama R, Asai N, Ohki M, Ohki Y, Kusubata K, Heissig B, Hattori K, Nakagawa Y, and Matsuda T.
Adipocyte-derived microvesicles are associated with multiple angiogenic factors and Induce Angiogenesis in Vivo and in Vitro.
Endocrinology. 151(6):2567-76,2010.

Sato Y, Ohki Y, Akiyama H, Rosenkvist J, Gritli I, Okumura K, Ogawa H, Daida H, Heissig B, Hattori K, Ohsaka A.
Targeted deletion of matrix metalloproteinase-9 reduces neutrophil accumulation during G-CSF-induced neoangiogenesis.
Cytometry Research. 19(2):53-62,2009.

Contributions of the fibrinolytic pathway to hematopoietic regeneration.
Heissig B, Ohki M, Ishihara M, Tashiro Y, Nishida C, Gritli I, Rosenkvist J, Hattori K.
J Cell Physiol. 221(3):521-5,2009.

Kerbel RS, Benezra R, Lyden DC, Hattori K, Heissig B, Nolan DJ, Mittal V, Shaked Y, Dias S, Bertolini F, Rafii S.
Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas.
Proc Natl Acad Sci U S A. 105(34):E54,2008.

Nishikii H, Eto K, Tamura N, Hattori K, Heissig B, Kanaji T, Sawaguchi A, Goto S, Ware J, Nakauchi H.
Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells.
J Exp Med. 205(8):1917-27,2008.

Heissig B, Lund LR, Akiyama H, Ohki M, Morita Y, Rømer J, Nakauchi H, Okumura K, Ogawa H, Werb Z, Danø K, Hattori K.
The plasminogen fibrinogen pathway is required for hematopoietic regeneration.
Cell Stem Cell. (16):658–670,2007.

Kiaei M, Kipiani K, Calingasan NY, Wille E, Chen J, Heissig B, Rafii S, Lorenzl S, Beal MF.
Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis.
Exp. Neurol. 205(1):74-81,2007.

Jin DK, Shido K, Kopp HG, Petit I, Shmelkov SV, Young LM, Hooper ATA, Amano H, Avecilla ST, Heissig B, Hattori K, Zhang F, Hicklin DJ, Wu Y, Zhu Z, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Rafii. S.
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4+ hemangiocytes.
Nature Med. 12(5):557-97, 2006.

Fietz T, Hattori K, Thiel E, Heissig B.
Increased soluble urokinase plasminogen activator receptor (suPAR) serum levels after granulocyte colony-stimulating factor treatment do not predict successful progenitor cell mobilization in vivo.
Blood.. 107(8):3408-9,2006.

Heissig B, Rafii S, Akiyama H, Ohki Y, Sato Y, Rafael T, Zhu Z, Hicklin DJ, Okumura K, Werb Z, Hattori K.
Low-dose irradiation promotes tissue revascularisation through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilization.
J. Exp. Med. 202(6):739-50,2005.

Ohki Y, Heissig B, Sato Y, Akiyama H, Zhu Z, Hicklin DJ, Shimada K, Ogawa H, Daida H, Hattori K, Ohsaka A.
Granulocyte-Colony Stimulating Factor promotes neovascularization by releasing vascular endothelial growth factor from neutrophils.
FASEB J.  19(14):2005-7,2005.

Heissig B, Ohki Y, Sato Y, Rafii S, Werb Z, Hattori K.
A role for niches in hematopoietic cell development.
Hematology. 10(3):247-53,2005.

Heissig B, Avecilla ST, Hattori K, Tejada R, Liao F, Shido K, Jin DK, Dias S, Zhang F, Hartman TE, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, de Sauvage F, Rafii S.
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis.
Nature Med. 10(1):64-71,2004.

Heissig B, Werb Z, Rafii S, Hattori K.
Role of c-kit/kit ligand signaling in regulating vasculogenesis.
Thromb Haemost. 90 (4):570-6,2003.

Rafii S, Avecilla S, Shmelkov S, Shido K, Tejada R, Moore MA, Heissig B, Hattori K.
Angiogenic factors reconstitute hematopoiesis by recruiting stem cells from bone marrow microenvironment.
Ann N Y Acad Sci.  996:49-60,2003.

Rabbany SY, Heissig B, Hattori K, Rafii S.
Molecular pathways regulating mobilization of marrow-derived stem cells for tissue revascularization.
Trends Mol Med. 9(3):109-17,2003.

Heissig B, Hattori K, Friedrich M, Rafii S, Werb Z.
Angiogenesis: vascular remodeling of the extracellular matrix involves metalloproteinases.
Curr Opin Hematol.. 10(2):136-141,2003.

Hattori K, Heissig B, Rafii S.
The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.
Leuk Lymphoma. 44(4):575-82,2003.

Salven P, Hattori K, Heissig B, Rafii S.
Interleukin-1alpha promotes angiogenesis in vivo via VEGFR-2 pathway by inducing inflammatory cell VEGF synthesis and secretion.
FASEB J. 16(11):1471-3,2002.

Heissig B*, Hattori K*, Dias S, Ferris B, Friedrich M, Ferris B, Hackett NR, Lyden D, Crystal RG, Besmer P, Moore MAS, Werb Z, Rafii S. (* The authors contributed equally to this work.)
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Cell. 109(5):625-637,2002.

Heissig B*, Hattori K*, Wu Y, Tejada R, Hicklin D, Zhu Z, Bohlen P, Witte L, Ferris B, Dias S, Hendriks J, Hacket NR, Crystal RG, Moore MAS, Werb Z, Lyden D, Rafii S. (* The authors contributed equally to this work.)
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment.
Nature Med. 8(8):841-849,2002.

Rafii S, Meeus S, Dias S, Hattori K, Heissig B, Shmelkov S, Rafii D, Lyden D.
Contribution of marrow-derived progenitors to vascular and cardiac regeneration.
Semin Cell Dev Biol. 13(1):61-67,2002.

Rafii S, Lyden D, Benezra R,Hattori K, Heissig B.
Vascular and haematopoietic stem and progenitor cells: novel targets for anti-angiogenesis therapy?
Nat Rev Cancer. 2(11):826-35,2002.

Rafii S, Meeus S, Dias S, Hattori K, Heissig B, Shmelkov S, Rafii D, Lyden D.
Contribution of marrow-derived progenitors to vascular and cardiac regeneration.
Semin Cell Dev Biol. 13(1):64-7,2002.

Rafii S, Heissig B, Hattori.
Efficient mobilization and recruitment of marrow-derived endothelial and hematopoietic stem cells by adenoviral vectors expressing angiogenic factors.
Gene Ther. 9(10):631-41,2002.

Sick C, Schultheis B, Pasternak G, Kottke I, Horner, Heissig B, Hehlmann R.
Predominantly BCR-ABL negative myeloid precursors in interferon-alpha treated chronic myelogenous leukemia: a follow-up study of peripheral blood colony-forming cells with fluorescence in situ hybridization.
Ann Hematol. 80(1):9-16,2001.

Hattori K, Dias S, Heissig B, Hackett N, Lyden D, Tateno M, Hicklin D, Zhu Z, Witte L, Crystal RG, Moore MAS, Rafii S.
Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells.
J Exp Med. 193(9):1005-14,2001.

Hattori K, Heissig B, Tashiro K, Honjo T, Tateno M, Hackett DJ, Quitoriano MS, Crystal RG, Rafii S, MAS Moore.
Plasma elevation of stromal cell-derived factor-1 induces mobilization of mature and immature hematopoietic progenitor and stem cells.
Blood. 97(11):3354-60,2001.

Moore MA, Hattori K, Heissig B, Shieh S, Crystal RG, Rafii S.
Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated elevation of serum levels of SDF-1, VEGF and angiopoietin-1.Mobilization of endothelial and hematopoietic stem and progenitor cells by adenovector-mediated ele
Ann N Y Acad Sci. 938:36-45,2001.

Dias S*, Hattori K*, Heissig B, Zhu Z, Wu Y, Witte L, Hicklin DJ, Tateno M, Bohlen P, Moore MAS, Rafii S. (* The authors contributed equally to this work.)
Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias.
Proc Natl Acad Sci U S A. 98(19):10857-62,2001.

Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z, Hackett NR, Crustal RG, Moore MAS, Hajjar KA, Manova K, Benezra R.
Impaired recruitment of bone marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth.
Nat Med. 7(11):1194-201,2001.

Heissig B, Pasternak G, Hörner S, Schwerdtfeger R, Rossol S, Hehlmann R.
CD14+ peripheral blood mononuclear cells from chronic myeloid leukemia and normal donors are inhibitory to short- and long-term cultured colony-forming cells.CD14+ peripheral blood mononuclear cells from chronic myeloid leukemia and normal donors are inhibitory to short- and long-term cultured colony-forming cells.
Leuk Res.. 24(3):217-31,2000.

Dias S, Hattori K, Zhu Z, Heissig B, Choy M, Lane W, Wu Y, Chadburn A, Hyjek E, Gill M, Hicklin D, Witte L, Moore MAS, Rafii S.
Autocrine stimulation of VEGF-R2 activates human leukemic cell growth and migration.
J Clin Invest.. 106(4):511-21,2000.

Lane WJ, Dias S, Hattori K, Heissig B, Choy M, Lam G, MAS Moore, Rafii S.
Stromal-derived factor 1-induced megakaryocyte migration and platelet production is dependent on matrix metalloproteinases.
Blood.. 96(13):4152-9,2000.

Schultheis B, Heissig B, Pasternak G, Hörner S, Hehlmann R.
Interferon-alpha-treated patients with chronic myelogenous leukemia show BCR/ABL-positive peripheral blood progenitor cells surviving long-term culture.
Folia Biol. 46(6):251-5,2000.

Pasternak G, Schultheis B, Heissig B, Hörner S, Sick C, Hehlmann R.
Does long-term culture favor normal clonogenic cells from interferon-treated patients with chronic myelogenous leukemia?
Leukemia.. 13 Suppl 1:S55-S64,1999.

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