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Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irié T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H, Hase K, Fukada T.
Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress.
PLOS Genetics. :,2016.

Wakisaka Y, Suzuki Y, Iwata O, Nakashima A, Ito T, Hirose M, Domon R, Sugawara M, Tsumura N, Watarai H, Shimobaba T, Suzuki K, Goda K, Ozeki Y.
Probing the metabolic heterogeneity of live Euglena gracilis with stimulated Raman scattering microscopy.
Nature Microbiol. 1(8):16124,2016.

Ushida M, Iyoda T, Kanamori M, Watarai H, Takahara K, Inaba K.
In vivo and in vitro analyses of α-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative.
Immunol Lett.. 168(2):300-305,2015.

Reynolds JM, Lee Y-H, Shi Y, Angkasekwinai P, Nallaparaju KC, Chang SH, Watarai H, Dong C.
Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation.
Immunity. 42(4):692-703,2015.

Shimizu K, Sato Y, Shinga J, Watanabe T, Endo TA, Asakura M, Kawahara K, Kinjo Y, Kitamura H, Tsuji M, Watarai H, Ishii Y, Taniguchi M, Ohara O, Fujii SI.
KLRG+ invariant natural killer T cells are long-lived effectors.
Proc Natl Acad Sci USA. 111(34):12474-12479,2014.

Ren Y, Dashtsoodol N, Watarai H, Koseki H, Quan C, Taniguchi M.
Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature natural killer T cell.
Int Immunol. 26(10):551-561,2014.

Shimizuhira C, Otsuka A, Honda T, Kitoh A, Egawa G, Nakajima S, Nakashima C, Watarai H, Miyachi Y, Kabashima K.
Natural killer T cells are essential for the development of contact hypersensitivity.
J Invest Dermatol. 134(11):2709-2718,2014.

Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis of RCAI-172 (C6 epimer of RCAI-147) and its biological activity.
Bioorg Med Chem. 22(2):827-833,2014.

Tarumoto N, Kinjo Y, Kitano N, Sasai D, Ueno K, Okawara A, Izawa Y, Shinozaki M, Watarai H, Taniguchi M, Takeyama H, Maesaki S, Shibuya K, Miyazaki Y.
Exacerbation of invasive Candida albicans infection by commensal bacteria or a glycolipid through IFN-γ produced in part by iNKT cells.
J Infect Dis. 209(5):799-810,2014.

Kitamura H, Kimura S, Shimamoto Y, Okabe J, Ito M, Miyamoto T, Naoe Y, Kikuguchi C, Meek B, Toda C, Okamoto S, Kanehira K, Hase K, Watarai H, Ishizuka M, El-Osta A, Ohara O, Miyoshi I.
Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation.
FASEB J. 27(12):4940-4953,2013.

Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis and biological activity of hydroxylated analogues of RCAI-80.
Tetrahedron. 69:9710-9715,2013.

Mera T, Itoh T, Kita S, Kodama S, Kojima D, Nishinakamura H, Okamoto K, Ohkura M, Nakai J, Iyoda T, Iwamoto T, Matsuda T, Baba A, Omori K, Ono J, Watarai H, Taniguchi M, Yasunami Y.
Pretreatment of donor islets with the Na+/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation.
Am J Transplant. 13(8):2154-2160,2013.

Tashiro T, Shigeura T, Shiozaki S, Watarai H, Taniguchi M, Mori K.
RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines.
Med Chem Commun. 4:949-955,2013.

Tashiro T, Nakagawa R, Shigeura T, Watarai H, Taniguchi M, Mori K.
RCAI-61 and related 6'-modified analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce interferon-g in vivo.
Bioorg Med Chem. 21(11):3066-3079,2013.

Shiozaki M, Tashiro T, Koshino H, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis and biological activity of hydroxylated analogues of KRN7000 (α-galactosylceramide).
Carbohydr Res . 370:46-66,2013.

Tarumoto N, Kinjo Y, Ueno K, Okawara A, Watarai H, Taniguchi M, Maesaki S, Miyazaki Y.
A limited role for iNKT cells in controlling systemic Candida albicans infection.
Jpn J Infect Dis. 65(6):522-528,2012.

Tashiro T, Shigeura T, Watarai H, Taniguchi M, Mori K.
RCAI-84, 91, and 105-108, ureido and thioureido analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines.
Bioorg Med Chem. 20(14):4540-4548,2012.

Watarai H, Yamada D, Fujii SI, Taniguchi M, Koseki H.
Induced pluripotency as a potential path towards iNKT cell-mediated cancer immunotherapy.
Int J Hematol. 95(6):624-631,2012.

Watarai H, Sekine-Kondo E, Motomura H, Yasuda T, Yoshida H, Kubo M, Koseki H, Taniguchi M
Development and function of invariant natural killer T cells producing TH2- and TH17-cytokines.
PLOS Biol. 10(2):e1001255,2012.

Tashiro T, Ishii Y, Shigeura T, Nakagawa R, Watarai H, Taniguchi M, Mori K.
RCAI-39, 41, 53, 100, 127 and 128, the analogues of KRN7000, activate mouse natural killer T cells to produce Th2-biased cytokines by their administration as liposomal particles.
Med Chem Comm. 2:620-625 ,2011.

Motomura Y, Kitamura H, Hijikata A, Matsunaga Y, Matsumoto K, Inoue H, Atarashi K, Hori S, Watarai H, Zhu J, Taniguchi M, Kubo M.
E4bp4, a mammalian basic leucine zipper transcriptinal factor, is a critical regulator of IL-10 and IL-13 production by CD4 T cells.
Nature Immunol. 12(5):450-459,2011.

Shiozaki M, Tashiro T, Koshino H, Nakagawa R, Inoue S, Shigeura T, Watarai H, Taniguchi M, Mori K.
Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000).
Carbohydr Res . 345(12):1663-1684,2010.

Watarai H, Fujii SI, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Harigaya KI, Koseki H, Taniguchi M.
Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells.
J Clin Invest. 120(7):2610–2618,2010.

2Tashiro T, Sekine-Kondo E, Shigeura T, Nakagawa R, Inoue S, Omori-Miyake M, Chiba T, Hongo N, Fujii SI, Shimizu K, Mori K, Yoshiga Y, Sumida T, Watarai H, Taniguchi M.
Induction of Th1-biased cytokine production by α-carba-GalCer, a neoglycolipid ligand for natural killer T cells.
Int Immunol. 22(4):319-328,2010.

Angkasekwinai P, Chang SH, Thapa M, Watarai H, Dong C.
Regulation of IL-9 expression by IL-25 signaling.
Nature Immunol. 11(3):250-256,2010.

Watarai H, Matsuoka N, Itoh T, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y.
High-mobility group box 1is involved in the initial events of early loss of transplanted islets in mice.
J Clin Invest. 120(3):735–743,2010.

Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M.
Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene.
Blood . 115(2):230-237,2010.

Taniguchi M, Tashiro T, Dashtsoodol N, Hongo N, Watarai H.
The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy.
Int Immunol. 22(1):1-6,2010.

Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.
Nature Cell Biol. 11(12):1427-1432,2009.

Tashiro T, Nakagawa R, Hirokawa T, Inoue S, Watarai H, Taniguchi M, Mori K.
RCAI-37, 56, 59, 60, 92, 101, and 102, cyclitol and carbasugar analogs of KRN7000: their synthesis and bioactivity for mouse lymphocytes to produce Th1-biased cytokines.
Bioorgan Med Chem . 17(17):6360-6373,2009.

Watarai H, Terashima A, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, Taniguchi M.
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity.
J Exp Med. 205(12):2727-2733,2008.

Hossain MB, Hosokawa H, Hasegawa A, Watarai H, Taniguchi M, Yamashita M, Nakayama T.
Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells.
Immunology. 125:377-386,2008.

Tashiro T, Nakagawa R, Inoue S, Shiozaki M, Watarai H, Taniguchi M, Mori K.
RCAI-61, the 6'-methylated analog of KRN7000: its synthesis and potent activity for mouse lymphocytes to produce interferon-γ in vivo.
Tetrahedron Lett. 49:6827-6830,2008.

Dashtsoodol N, Watarai H, Sakata S, Taniguchi M.
Identification of CD4-CD8- double-negative natural killer T cell precursors in the thymus.
PLOS ONE. 3(11):e3688,2008.

Tashiro T, Nakagawa R, Inoue S, Shiozaki M, Watarai H, Taniguchi M, Mori K.
RCAI-61, the 6'-methylated analog of KRN7000: its synthesis and potent activity for mouse lymphocytes to produce interferon-g in vivo.
Tetrahedron Lett. 49:6827-6830,2008.

Tashiro T, Hongo N, Nakagawa R, Seino KI, Watarai H, Ishii Y, Taniguchi M, Mori K.
RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: Their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines.
Bioorgan Med Chem. 16(19):8896-8906,2008.

Watarai H, Sekine E, Inoue S, Nakagawa R, Kaisho T, Taniguchi M.
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon.
Proc Natl Acad Sci U S A. 105(8):2993-2998,2008.

Watarai H, Nakagawa R, Omori-Miyake M, Dashtsoodol N, Taniguchi M.
Methods for detection, isolation and culture of mouse and human invariant NKT cells.
Nature Protoc. 3(1):70-78,2008.

Shinohara H, Maeda S, Watarai H, Kurosaki T.
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
J Exp Med. 204(13):3285-3293,2007.

Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K, Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, Ohara O.
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells.
Bioinformatics. 23(21):2934-2941,2007.

Tashiro T, Nakagawa R, Hirokawa T, Inoue S, Watarai H, Taniguchi M, Mori K.
RCAI-56, a carbocyclic analogue of KRN7000: its synthesis and potent activity for natural killer (NK)T cell to preferentially produce interferon-γ.
Tetrahedron Lett. 48(19):3343-3347,2007.

Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh WC, Akira S, Kitamura H, Ohara O, Seino K, Taniguchi M.
IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses.
J Exp Med. 203(13):2929-2937,2006.

Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, Numaga T, Mori Y, Iino M, Hikida M, Kurosaki T.
Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum.
Proc Natl Acad Sci U S A. 103(45):16704-16709,2006.

Jiang X, Morita M, Sugioka A, Harada M, Kojo S, Wakao H, Watarai H, Ohkohchi N, Taniguchi M, Seino K.
The importance of CD25+ CD4+ regulatory T cells in mouse hepatic allograft tolerance.
Liver Transplant. 12(7):1112-1118,2006.

Shinohara H, Yasuda T, Aiba Y, Sanjo H, Hamadate M, Watarai H, Sakurai H, Kurosaki T.
PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1.
J Exp Med. 202(10):1423-14231,2005.

Watarai H, Hinohara A, Nagafune J, Nakayama T, Taniguchi M, Yamaguchi Y.
Plasma membrane-focused proteomics: dramatic changes in surface expression during the maturation of human dendritic cells.
Proteomics. 5(15):4001-4011,2005.

Kojo S, Seino K, Harada M, Watarai H, Wakao H, Uchida T, Nakayama T, Taniguchi M.
Induction of regulatory properties in dendritic cells by Vα14 NKT cells.
J Immunol. 175(6):3648-5365,2005.

Jiang X, Shimaoka T, Kojo S, Harada M, Watarai H, Wakao H, Ohkohchi N, Yonehara S, Taniguchi M, Seino K.
Cutting edge: critical role of CXCL16/CXCR6 in NKT cell trafficking in allograft tolerance.
J Immunol. 175(4):2051-2055,2005.

Kimura MY, Hosokawa H, Yamashita M, Hasegawa A, Iwamura C, Watarai H, Taniguchi M, Takagi T, Ishii S, Nakayama T.
Regulation of T helper type 2 cell differentiation by murine Schnurri-2.
J Exp Med. 201(3):397-408,2005.

Feese MD, Tamada T, Kato Y, Maeda Y, Hirose M, Matsukura Y, Shigematsu H, Muto T, Matsumoto A, Watarai H, Ogami K, Tahara T, Kato T, Miyazaki H, Kuroki R.
Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment.
Proc Natl Acad Sci U S A. 101(7):1816-1821,2004.

Kuroki R, Hirose M, Kato Y, Feese MD, Tamada T, Shigematsu H, Watarai H, Maeda Y, Tahara T, Kato T, Miyazaki H.
Crystallization of the functional domain of human thrombopoietin using an antigen-binding fragment derived from neutralizing monoclonal antibody.
Acta Crystallogr D Biol Crystallogr. 58(Pt 5):856-858,2002.

Watarai H, Nozawa R, Tokunaga A, Yuyama N, Tomas M, Hinohara A, Ishizaka K, Ishii Y.
Posttranslational modification of the glycosylation inhibiting factor (GIF) gene product generates bioactive GIF.
Proc Natl Acad Sci U S A. 97(24):13251-13256,2000.

Watarai H, Inagaki Y, Kubota N, Fuju K, Nagafune J, Yamaguchi Y, Kadoya T.
Proteomic approach to the identification of cell membrane proteins.
Electrophoresis. 21(2):460-464,2000.

Tomura T, Watarai H, Honma N, Sato M, Iwamatsu A, Kato Y, Kuroki R, Nakano T, Mikayama T, Ishizaka K.
Immunosuppressive activities of recombinant glycosylation-inhibiting factor mutants.
J Immunol. 162(1):195-202,1999.

Yanagihara S, Komura E, Nagafune J, Watarai H, Yamaguchi Y.
EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation.
J Immunol. 161(6):3096-3102,1998.

Tahara T, Kuwaki T, Matsumoto A, Morita H, Watarai H, Inagaki Y, Ohashi H, Ogami K, Miyazaki H, Kato T.
Neutralization of biological activity and inhibition of receptor binding by antibodies against human thrombopoietin.
Stem Cells. 16(1):54-60,1998.

Nakano T, Watarai H, Liu YC, Oyama Y, Mikayama T, Ishizaka K.
Conversion of inactive glycosylation inhibiting factor to bioactive derivatives by modification of a SH group.
Proc Natl Acad Sci USA.. 94(1):202-207,1997.

Kato T, Oda A, Inagaki Y, Ohashi H, Matsumoto A, Ozaki K, Miyakawa Y, Watarai H, Fuju K, Kokubo A, Kadoya T, Ikeda Y, Miyazaki H.
Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin.
Proc Natl Acad Sci U S A. 94(9):4669-4774,1997.

Kato Y, Muto T, Tomura T, Tsumura H, Watarai H, Mikayama T, Ishizaka K, Kuroki R.
The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded β-sheets.
Proc Natl Acad Sci U S A. 93(7):3007-3010,1996.

Ishii Y, Nakano T, Honma N, Yuyama N, Yamada Y, Watarai H, Tomura T, Sato M, Tsumura H, Ozawa T, Mikayama T, Ishizaka K.
Preparation of soluble recombinant T cell receptor alpha chain by using a calmodulin fusion expression system.
J Immunol Methods. 186(1):27-36 ,1995.

Nakano T, Liu YC, Mikayama T, Watarai H, Taniguchi M, Ishizaka K.
Association of the "major histocompatibility complex subregion" I-J determinant with bioactive glycosylation-inhibiting factor.
Proc Natl Acad Sci U S A. 92(20):9196-9200,1995.

Nakayama J, Watarai H, Nagasawa H, Isogai A, Clewell DB, Suzuki A.
Immunological characterization of pheromone-induced proteins associated with sexual aggregation in Enterococcus faecalis.
Biosci Biotechnol Biochem. 56(2):264-269,1992.

Nakayama J, Watarai H, Isogai A, Clewell DB, Suzuki A.
C-terminal identification of AD74, a proteolytic product of Enterococcus faecalis aggregation substance: application of liquid chromatography/mass spectrometry.
Biosci Biotechnol Biochem. 56(1):127-131,1992.

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