From Bench To Bedside: Understanding the dynamics of stem cell-associated diseases Only those who attempt the absurd can achieve the impossible. Albert Einstein

Current News

2016/03/23

FY 2016 - Openings for Master and PhD students (Open Lab Information)
Open lab: Saterday, April 23(13:00-17:00) and Saturday, May 14 (10:00-12:30), 2016. Please call the lab on the day of the open lab (or even before) (phone number: 03-6409-2108), so we will set a time to meet you.

1.Research Objectives

We are investigating the mechanisms that regulate hematopoietic stem cell function in the hematopoietic system. Our goal is to integrate what we know about stem cells in different tissues to understand the extent to which they employ similar or different mechanisms to regulate critical functions. We are using genetic and cell biological approaches to identify candidate mediators of the self-renewal program in hematopoietic stem cells. Since cancer cells seem to copy these self-renewal mechanisms, we also evaluate the role these mechanisms play in cancer. Our goal is to provide an international platform for vivid scientific exchange that performs cutting-edge, but highly competitive research with the potential to be translated into the clinic.

 

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2. Research Projects

1. Development of methods to expand adult stem cells

Keywords: adult hematopoietic stem cells, mesenchymal stem cells, cytokines, expansion

Mesenchymal stem cells (MSCs) hold great potential for the treatment of various degenerative diseases and immune disorders, largely because of their differentiation potential and immunoregulatory capacity. MSCs can differentiate into osteoblasts, chondrocytes and adipocytes. For instance, damage to muscles heals very slowly. However, if there were a method of activating the MSCs, then such wounds would heal much faster. The bone marrow (BM) is one of the major sources of MSC. Although the exact molecular mechanisms that govern MSC expansion and migration are not fully characterized, this migratory ability points to MSCs as attractive candidates for delivery vehicles of antitumor agents. But like most stem cells, MSC numbers are limited. The Heissig laboratory is currently focused on understanding the nature of MSC mobilization and expansion.

The great challenge ahead is to expand MSCs and to characterize the function of these expanded cells in various disease models, including their potential of MSCs for organ regeneration, to immunological and malignant diseases.

 

2. Elucidation of molecular mechanisms governing normal and pathological angiogenesis

Keywords: cancer, myeloid cells, proteases, angiogenesis, ischemia, blood cells

Endothelial cells are part of the microenvironment and can form blood vessels, a process known as angiogenesis. Excess angiogenesis promotes the progression of numerous diseases, including cancer, inflammation, infection etc. Inhibition of angiogenesis has thus emerged as an attractive therapeutic strategy to combat various diseases. We are focused on studying the mechanism of action of novel angiogenic factors or their inhibitors and test their clinical potential in angiogenesis-associated diseases like in cancer or ischemia.



 

 

 

 

 

 

 

 

 

 

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About the Center for Stem Cell Biology and Regenerative Medicine, IMSUT
Center for Stem Cell Biology and Regenerative Medicine, IMSUT
Research Organizations

Division of Stem Cell Dynamics, Center for Stem Cell Biology and Regenerative Medicine, IMSUT 4-6-1 Shirokanedai Minato-ku, Tokyo, 108-8639, Japan -81-3-6409-2108 +81-3-6409-2109 dynamics@ims.u-tokyo.ac.jp

  • Center for Stem Cell Biology and Regenerative Medicine, IMSUT
  • Institute of Medical Science, the University of Tokyo
  • The University of Tokyo

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